Disclosure: Some links on this site are affiliate links. If you purchase through these links, we may earn a commission at no extra cost to you. Thank you for supporting our site.·For informational purposes only—not medical advice.
Fact-checked by WPG editorial staff against primary sources: FDA.gov, provider websites (verified March 30, 2026), Trustpilot.com, and peer-reviewed clinical trials (NEJM, JAMA). Last verified: March 30, 2026.
MEDVi vs TrimRx: Which GLP-1 Program Is Actually Worth Your Money?

The Short Answer (So You Don't Have to Scroll)
If you're comparing MEDVi vs TrimRx for compounded GLP-1 weight loss medication, here's the short answer: MEDVi wins for most people. MEDVi now operates as a hybrid platform: compounded semaglutide injection starting at $179/mo, compounded tirzepatide injection from $349/mo or tablets from $279/mo, plus brand-name options (Wegovy pill, Wegovy injection, Zepbound injection) available through a $99/mo membership plus medication cost. Over 11,498 Trustpilot reviews at 4.4/5 stars, LegitScript-certified, and zero supplement upsells.
TrimRx wins if you commit to a longer plan — their 6-month semaglutide plan drops to $191/mo and 12-month to $174/mo, beating MEDVi's $299/mo refill rate. TrimRx also offers bundled GLP-1 supplements if you want them.
Skip both if your insurance covers Wegovy, Ozempic, or Zepbound. Brand-name FDA-approved medications are the gold standard — and with oral Wegovy now available (FDA-approved December 2025), you have more options than ever. Check your formulary first.
Side-by-Side: MEDVi vs TrimRx at a Glance
Every row below was verified against each provider's official website. Where we couldn't confirm a claim, we say so.

60-second decision snapshot: MEDVi vs TrimRx key differences at a glance.
| Category | MEDVi | TrimRx |
|---|---|---|
| Semaglutide Price | Injection: $179/mo (Month 1) → $299/mo (refills) · Tablets: $249/mo (Month 1) → $369/mo (refills) | $299/mo ($179 limited promo); 3-mo $209/mo; 6-mo $191/mo; 12-mo $174/mo |
| Tirzepatide Price | Injection: from $349/mo (intro) · Tablets: from $279/mo (intro) | $399/mo ($279 limited promo); 3-mo $316/mo; 6-mo $299/mo; 12-mo $283/mo |
| What's Included | Medication, provider consults, shipping, 24/7 messaging | Medication, provider consults, shipping, 24/7 support |
| Supplement Upsells | None | Yes — GLP-1 Daily Support ($119/mo), Weight Loss Boost ($149/mo) |
| Medication Source | States partnership with "multiple USA certified pharmacies"; third-party sources (ConsumerAffairs, VaccineAlliance) identify Belmar Pharma Solutions and Beluga Health as partners | Compounding pharmacies (not publicly named) |
| Trustpilot Rating | 4.4/5 — 11,498 reviews | ~3.4/5 — ~635 reviews |
| Money-Back Guarantee | Yes — see current refund policy on MEDVi.org | Advertises a results guarantee (terms vary; see current checkout terms) |
| Contracts | None — cancel anytime | None — cancel anytime (multi-month plans billed upfront) |
| LegitScript Certified | Yes | Not listed |
| Provider Network | OpenLoop Health (licensed in your state) | Telehealth providers (network not publicly named) |
| Cancellation | 72 hours before billing date; cancel via email or account | Cancel via chat or call 888-896-1612; some reviewers report friction |
| HSA/FSA | Accepted | Check with your specific plan |
| Financing | Not advertised | Affirm / Klarna / Afterpay may be offered (APR and terms vary) |
| Senior Discount | $50/mo off for 65+ | Not advertised |
Pricing observed on MEDVi.org and TrimRx checkout page, captured March 30, 2026. Promotional pricing may change — always confirm in your cart before completing payment.
Important: Both MEDVi and TrimRx provide compounded semaglutide and tirzepatide. Compounded medications are not FDA-approved products. The FDA warns that some compounded products sold as "semaglutide" may use salt forms (e.g., semaglutide sodium or acetate), which the FDA says are different active ingredients than those in the approved drugs. We cover this in detail in our safety section.
Who Should Pick Which (and Who Should Skip Both)
Pick MEDVi If You Want…
- Straightforward monthly pricing with no commitments — $179/mo to start semaglutide, $349/mo for tirzepatide injection, or $279/mo for tirzepatide tablets. No multi-month contracts required.
- A tirzepatide tablet option — MEDVi offers oral tirzepatide at $279/mo, which is the lowest tirzepatide entry point between these two providers.
- Review volume you can actually trust — 11,498 Trustpilot reviews at 4.4/5 stars. That's not a handful of cherry-picked testimonials. That's a dataset.
- No surprise charges — What you see is what you pay. No supplement bundles added at checkout, no mystery fees on your statement.
- LegitScript certification — Third-party verification that the business meets pharmacy practice standards. You can verify this yourself at LegitScript.com.
- A money-back guarantee — MEDVi advertises a weight loss money-back guarantee. Review their current refund policy at MEDVi.org for specific terms before enrolling.
Pick TrimRx If You Want…
- Lower semaglutide pricing on longer plans — TrimRx's 6-month plan drops to $191/mo and the 12-month to $174/mo, both beating MEDVi's $299/mo refill rate. If you know you're committing for 6+ months, this is real savings.
- GLP-1 supplements included in your plan — If you were going to buy metabolism or appetite-support supplements anyway, TrimRx bundles them (though they're optional add-ons, not free).
- 3-month medication shipments — Fewer shipments, fewer tracking numbers, fewer trips to the mailbox.
- Financing options — TrimRx offers installment payments through Affirm, Klarna, and Afterpay on multi-month plans (APR and terms vary by eligibility).
Skip Both If…
- Your insurance covers Wegovy, Ozempic, or Zepbound. FDA-approved, clinically tested at specific concentrations, covered by your plan. That's the best-case scenario.
- You qualify for manufacturer savings cards. Novo Nordisk and Eli Lilly both offer savings programs that can dramatically reduce out-of-pocket costs.
- Oral Wegovy is available to you. The FDA approved an oral formulation of semaglutide (Wegovy) in December 2025, and it's entering the market in early 2026. If you prefer pills over injections, ask your provider.
- You can get brand-name Ozempic through NovoCare's self-pay program. Novo Nordisk currently offers Ozempic at $349/month for the 0.25 mg, 0.5 mg, or 1 mg doses ($499/mo for 2 mg), with a limited introductory offer of $199/month for new patients on lower doses through March 31, 2026. Verify current terms and your dose eligibility at NovoCare.com.
MEDVi: The Full Picture
Pricing — What You'll Actually Pay
Let's start with the number that matters: Month 1 is not the same as Month 2.
MEDVi's semaglutide program starts at $179 for your first month. That jumps to $299/month on refills. For tirzepatide, MEDVi offers two formats: injection at $349/month and tablets at $279/month. MEDVi also offers semaglutide tablets at $249 for the first month, with refills at $369/month — for those who prefer a daily dissolvable pill over weekly injections. Confirm your specific refill pricing during checkout, as pricing may vary by dose or product.
We'll be honest — that $179-to-$299 semaglutide jump catches people off guard. Multiple reviewers mention being surprised by the refill price. If you're budgeting, plan for the ongoing rate, not the intro price.
Context matters. TrimRx's regular monthly semaglutide price is also $299/mo (with the same $179 promotional intro). The compounded semaglutide market in 2026 ranges from roughly $175 to $399/month across major providers. At $299, both MEDVi and TrimRx sit in the competitive middle. Where they diverge is plan structure — TrimRx offers multi-month discounts; MEDVi keeps it month-to-month. Use our GLP-1 cost finder to compare across providers.
Real Cost Over Time
| Timeframe | MEDVi Sema | MEDVi Tirz (Inj) | TrimRx Sema (Monthly) | TrimRx Sema (6-mo) | TrimRx Tirz (Monthly) |
|---|---|---|---|---|---|
| Month 1 | $179 | $349 | $179 (promo) | $191/mo | $279 (promo) |
| 3 Months | $777 | $1,047 | $777 | $573 | $1,077 |
| 6 Months | $1,674 | $2,094 | $1,674 | $1,146 | $2,274 |
| 12 Months | $3,468 | $4,188 | $3,468 | $2,292 | $4,668 |
MEDVi pricing assumes $179 Month 1 then $299/mo for semaglutide injection, and $349/mo intro for tirzepatide injection (note: multiple third-party reviews report tirzepatide refills may increase with dose escalation, potentially reaching $399–$499/mo — confirm your specific refill rate in writing). TrimRx monthly pricing assumes $179 promo Month 1 then $299/mo for semaglutide and $279 promo Month 1 then $399/mo for tirzepatide. TrimRx multi-month plans are billed upfront. Adding supplements ($119–$149/mo) increases TrimRx totals significantly.
Additional Pricing Details Worth Knowing
MEDVi accepts HSA and FSA payments, which effectively means you can use pre-tax dollars — saving roughly 25–35% depending on your tax bracket. On a $299/month plan, that's like paying $194–$224 in after-tax dollars. If you have HSA/FSA funds sitting unused, this is one of the better ways to deploy them.
Seniors 65+ get $50/month off — bringing semaglutide to $249/month ongoing and tirzepatide injection to $299/month. For older adults on a fixed income, this makes MEDVi highly competitive.
Shipping is included in every plan. There are no consult fees beyond the monthly plan cost, no hidden admin charges, and no enrollment fees. No contracts, no commitments. Cancel before your next billing cycle and you won't be charged again.
Reviews — What 11,498 People Actually Said
MEDVi's Trustpilot profile is one of the strongest in the compounded GLP-1 space. As of March 2026, they have 11,498 reviews with a 4.4 out of 5 star rating. That's not manufactured enthusiasm — it's a large enough sample that patterns become reliable.
Reviewer 1 (Trustpilot): One user described losing over 30 pounds and dropping multiple clothing sizes. She said the experience restored her confidence after years of struggling, and that the process felt straightforward with responsive support when she had questions.
Reviewer 2 (Trustpilot): Another reviewer admitted he was nervous after reading negative reviews online. Six months in, he reported zero issues with billing, medication quality, or support — saying the negative reviews didn't match his experience at all.
Reviewer 3 (Trustpilot): A tirzepatide user reported going from 158 to 138 pounds. She described the process as uncomplicated and said she felt like she had her body from her mid-twenties back.
These are paraphrased summaries of public Trustpilot reviews. Visit Trustpilot.com/review/medvi.org to read the original reviews in full.
The complaints you should know about: The most common negative reviews mention refill delays, occasional shipping hiccups, and offshore customer support. MEDVi has replied to approximately 99% of negative Trustpilot reviews as of March 2026. Whether that response translates to full resolution varies by case, but the pattern of active engagement is there.
How It Works — From Quiz to Your Doorstep
- Complete an online questionnaire. Medical history, weight loss goals, current medications. Takes about 10 minutes.
- Provider review. A licensed provider through the OpenLoop Health network reviews your information. These are physicians and nurse practitioners licensed in your state.
- Prescription and shipment. If approved, your compounded medication ships from one of MEDVi's U.S. partner pharmacies. Typical delivery is 3–7 business days.
- Ongoing support. Unlimited 24/7 messaging with your care team. Dosage adjustments as needed. Monthly shipments unless you cancel.
MEDVi ships to most U.S. states; availability varies by state and medication format — confirm during your intake.
TrimRx: The Full Picture
Pricing — Plan-Based Savings and Hidden Costs
TrimRx uses a plan-based pricing model where longer commitments unlock lower monthly rates. As observed on TrimRx's checkout page in March 2026:
Semaglutide:
- Monthly: $299/mo (with a "$179 limited offer" promotion)
- 3-month plan: $209/mo
- 6-month plan: $191/mo
- 12-month plan: $174/mo
Tirzepatide:
- Monthly: $399/mo (with a "$279 limited offer" promotion)
- 3-month plan: $316/mo
- 6-month plan: $299/mo
- 12-month plan: $283/mo
Pricing captured from TrimRx checkout, March 2026. Pricing may vary by offer or plan length — always confirm in your cart.
For someone who knows they're committing to 6–12 months of treatment, TrimRx's multi-month plans offer meaningful savings over MEDVi's month-to-month model. At $174/mo for 12-month semaglutide, TrimRx is roughly $125/mo cheaper than MEDVi's $299 refill rate — that's $1,500/year in savings.
The Supplement Upsell Problem
TrimRx actively promotes supplement add-ons during the signup process. Some Trustpilot reviewers report that the upsells are presented aggressively during checkout, and a few indicate they weren't entirely clear on what they'd agreed to until they saw their credit card statement.
| Plan | Base Price (Monthly) | + Daily Support | + Weight Loss Boost | + Both Supplements |
|---|---|---|---|---|
| Semaglutide | $299 | $418 | $448 | $567 |
| Tirzepatide | $399 | $518 | $548 | $697 |
At $567–$697/month, TrimRx stops being a budget option. It becomes one of the more expensive programs in the space. Our recommendation: If you choose TrimRx, screenshot your cart before confirming. Know exactly what you're paying for. Decline supplements at checkout unless you specifically want them.

Always screenshot your cart and save confirmation emails before paying any GLP-1 provider.
Reviews — A Smaller, More Mixed Picture
TrimRx has approximately 630 Trustpilot reviews with a rating around 3.4 out of 5 stars as of March 2026. That's a significantly smaller review pool than MEDVi's, and a noticeably lower rating. It doesn't mean TrimRx is a scam — but it does mean you have less data to work with. See our detailed TrimRx review.
What supporters say: Several reviewers praise the 3-month supply model, noting fewer shipments and better consistency. Others mention that when issues arose, staff resolved them through refunds or replacements. Some reviewers specifically mention the supplement bundles positively.
What critics say: Some reviewers report billing amounts that differed from what they expected at signup. TrimRx's Better Business Bureau profile also shows complaints, with themes including billing discrepancies, cancellation friction, and charges appearing after cancellation requests.
Fair assessment: TrimRx has both passionate supporters and genuine critics. The billing-related complaint pattern is worth paying attention to — we'd recommend documenting everything. Screenshot your order confirmation, save email receipts, and set calendar reminders before your next billing date.
How It Works — Quiz to Quarterly Shipments
- Take the online quiz. Health background, goals, preferences. Standard intake questionnaire similar to MEDVi's. Takes about 10–15 minutes.
- Provider consultation. A telehealth provider reviews your information and determines eligibility. TrimRx does not publicly name its provider network.
- Select your plan. Choose semaglutide or tirzepatide, and your plan length. This is also where supplement add-ons are presented. Pay attention to what's checked or pre-selected in your cart before confirming.
- Receive medication. TrimRx ships 3-month supplies on longer plans. Multi-month plans can be financed through Affirm, Klarna, or Afterpay.
Transparency gap: TrimRx does not publicly name its compounding pharmacy partners. This isn't automatically disqualifying — some legitimate providers keep pharmacy relationships private. But it does mean you can't independently verify the source, licensing status, or FDA registration of the pharmacy producing your medication without asking TrimRx directly. If transparency matters to you, ask TrimRx for the name and license number of their compounding pharmacy before you pay.
Honest Tradeoffs: Where Each One Wins and Where Neither Is Perfect
Where MEDVi Clearly Wins
- Review volume and rating. Over 11,498 reviews at 4.4/5 vs. ~635 reviews at ~3.4/5 isn't close. MEDVi has roughly 18 times the review volume and about 1.0 star higher in rating.
- No supplement upsells. Your monthly fee is your monthly fee. Period.
- LegitScript certification. Third-party compliance verification. TrimRx is not listed.
- Tirzepatide tablet option. MEDVi's $279/mo tirzepatide tablets are the lowest tirzepatide entry point between these two providers — and it's an oral option.
- No multi-month commitment required. Month-to-month. Cancel anytime with 72 hours notice.
- Senior discount. $50/month off for 65+.
Where TrimRx Has a Real Edge
- Lower semaglutide pricing on longer plans. Their 6-month plan at $191/mo and 12-month at $174/mo significantly beat MEDVi's $299/mo ongoing rate. Over a year, that's $1,296–$1,500 in savings.
- Financing options. Installment payments through Affirm, Klarna, and Afterpay (APR and terms vary by eligibility). MEDVi doesn't advertise similar financing.
- Supplement bundles. If you were already planning to buy GLP-1 support supplements separately, getting them through your medication provider means one less vendor to manage.
- 3-month shipments. Fewer deliveries, more convenience, less chance of running out if shipping gets delayed.
Where They're Essentially Equal
Both MEDVi and TrimRx provide compounded medications (not FDA-approved products). Both are cash-pay only — neither bills insurance. Both use telehealth consultations. Both offer free shipping. Both have no long-term contracts (though TrimRx's multi-month plans are billed upfront). Both offer a $179 promotional semaglutide intro price. And neither publicly names its compounding pharmacy partners on its website — though MEDVi states it works with "multiple USA certified pharmacies" and you should ask either provider for the specific pharmacy name.
What Neither Provider Will Tell You
These are the uncomfortable truths that neither MEDVi's nor TrimRx's marketing department will volunteer. They're not disqualifying — but they're worth knowing before you commit several hundred dollars a month.
- Compounded GLP-1 medications are not FDA-approved. The FDA warns that some products sold as "semaglutide" may use salt forms which the FDA says are different active ingredients than those used in the approved drugs. Read more: Is Compounded Semaglutide Safe?
- The FDA has raised specific additional concerns about contamination during compounding, incorrect concentrations, and dosing errors. The FDA reports over 600 adverse event reports associated with compounded semaglutide and over 500 associated with compounded tirzepatide as of July 2025.
- Shortage exemptions ended on specific dates. The tirzepatide shortage was resolved on October 2, 2024. The semaglutide injection shortage was resolved on February 21, 2025. As of May 2026, lawful patient-specific compounding still occurs under existing pharmacy law, but the broad shortage-based exemptions are gone. 503B note: For semaglutide and tirzepatide, the FDA has stated those substances are not on the current 503B bulks list or shortage list — do not treat “503B” alone as proof that a compounded GLP-1 is FDA-approved or legally available.
- Side effects are real and common. Nausea (44%), diarrhea (30%), vomiting (25%), and constipation (24%) per the Wegovy prescribing label.
- Weight loss is not guaranteed. Approximately 10–15% of patients are considered non-responders.
- You'll probably need to stay on the medication long-term. The STEP 1 extension trial showed most participants regained approximately two-thirds of their lost weight within one year of stopping semaglutide.
- Neither provider replaces your primary care doctor. Your regular doctor should know you're on a GLP-1 medication, especially if you take other prescriptions or have a history of pancreatitis or thyroid issues. See GLP-1 contraindications.
How to Maximize Your Results (Regardless of Which Provider You Choose)
Since both MEDVi and TrimRx deliver the same active medications, your results depend heavily on what you do alongside the prescription. Here's what the clinical evidence and real-world results suggest:
- Protein intake matters more than you think. GLP-1 medications reduce appetite broadly, meaning you'll eat less of everything — including protein. Aim for 0.7–1.0 grams of protein per pound of goal body weight daily. Learn more: How to prevent muscle loss on GLP-1s.
- Move your body, but don't obsess over cardio. Resistance training (weights, bodyweight exercises, resistance bands) helps preserve muscle mass. Even 2–3 sessions per week makes a measurable difference. Walking 7,000–10,000 steps daily supports overall metabolic health.
- Hydrate aggressively. GLP-1 medications can contribute to dehydration, which worsens nausea and constipation. Aim for at least 64 ounces of water daily.
- Track something. Whether it's weight, measurements, photos, or how your clothes fit — track at least one metric weekly.
- Don't try to out-diet the medication. Severe calorie restriction increases muscle loss, crashes energy, and creates an unsustainable relationship with food. Eat when you're hungry, choose nutritious foods, prioritize protein, and let the medication do its job.

Practical tips for your first month on GLP-1 medication — based on clinical guidelines and real patient experience.
How We Verified Everything
We don't publish claims we can't source. Here's exactly how we evaluated MEDVi and TrimRx across eight criteria. Read our full methodology.
1. Pricing
Verified directly from official websites (MEDVi.org and TrimRx checkout page) in March 2026. We documented intro prices, ongoing prices, plan-based pricing tiers, and add-on costs. We did not rely on third-party comparison sites.
2. Trustpilot Data
Checked directly at Trustpilot.com in March 2026. Review counts and star ratings are reported as of that date and will change over time.
3. Pharmacy Transparency
MEDVi's own website states it works with "multiple USA certified pharmacies" without naming them. However, multiple independent sources (ConsumerAffairs, VaccineAlliance) identify Belmar Pharma Solutions and Beluga Health as MEDVi's pharmacy partners. TrimRx does not publicly name its compounding pharmacy partners. We recommend confirming the dispensing pharmacy directly with either provider.
4. Regulatory Compliance
We checked LegitScript certification status and reviewed FDA communications regarding compounded semaglutide and tirzepatide through March 2026, including the FDA's concerns page (FDA.gov) and shortage resolution timeline.
5. What's Included
We verified what each monthly fee covers (medication, consults, shipping) and what costs extra (supplements, add-ons).
6. Cancellation Friction
We reviewed Trustpilot and BBB for patterns in cancellation difficulty and documented the cancellation process for each provider.
7. Clinical Support Model
We identified provider networks (where publicly available) and support channels.
8. Guarantee Terms
We verified money-back guarantee availability from official sources. Specific terms may change — always confirm current refund policy before enrolling.
Affiliate transparency: MEDVi is our primary recommendation and affiliate partner. TrimRx is a secondary recommendation. Every data point above is sourced and verifiable. If you find an error, contact us and we'll correct it within 24 hours. We re-verify pricing and reviews monthly. See our editorial standards and advertising disclosure.
What You Need to Know Before You Decide
Are Compounded GLP-1 Medications Safe?
Compounded semaglutide and tirzepatide are intended to use the same active ingredients as their FDA-approved counterparts (Ozempic/Wegovy and Mounjaro/Zepbound). However, the FDA warns that some products sold as "semaglutide" may actually contain salt forms — such as semaglutide sodium or semaglutide acetate — which the FDA says are different active ingredients than those in the approved drugs.
The final compounded products are not FDA-approved, meaning the agency does not review them for safety, effectiveness, or quality before they are marketed. The FDA has documented concerns including contamination during compounding, incorrect concentrations, dosing errors, and fraudulent labeling. Read our full analysis: Is Compounded Semaglutide Safe?

Safety checklist for compounded GLP-1 medications — verify these items before starting treatment.
How to Protect Yourself:
- Ask your provider for the pharmacy name and license number. This is non-negotiable. If they won't share it, walk away.
- Look up the pharmacy yourself. Check your state's Board of Pharmacy website and the FDA's Registered Drug Establishments database (FDA.gov).
- Ask about the salt form. Specifically ask whether they use semaglutide base (the form used in approved drugs) or a salt form like semaglutide sodium.
- Neither MEDVi nor TrimRx publicly names its pharmacy partners on its website. Ask either provider directly and verify independently before paying.
What Happened with the FDA Shortage Timeline?
Tirzepatide Shortage Resolved: October 2, 2024
FDA confirmed with Eli Lilly that their product availability and manufacturing capacity could meet national demand. FDA later issued a new declaratory order on December 19, 2024. The 503A enforcement discretion period ended February/March 2025, and the 503B period ended March 19, 2025.
Semaglutide Shortage Resolved: February 21, 2025
FDA confirmed with Novo Nordisk that supply could meet demand. The 503A enforcement discretion period ended April 2025, and the 503B period ended May 22, 2025.
March 2026 Reality
The FDA's enforcement focus is on unlicensed manufacturing, misleading marketing, fraudulent labeling, and use of salt forms without lawful basis — not on all lawful patient-specific compounding. Both MEDVi and TrimRx continue to operate.
What About Insurance?
Neither MEDVi nor TrimRx bills insurance. Both are cash-pay programs. If you have insurance that covers GLP-1 medications, check these options first:
- Wegovy (semaglutide injection) — for weight management, increasingly covered by commercial plans.
- Ozempic (semaglutide injection) — FDA-approved for type 2 diabetes, sometimes prescribed off-label for weight loss.
- Zepbound (tirzepatide injection) — for weight management, coverage expanding but still inconsistent.
- Oral Wegovy — FDA-approved December 2025. Daily pill formulation. Coverage is being established in early 2026.
Manufacturer savings programs: Novo Nordisk offers a self-pay program through NovoCare where eligible patients may pay $349/month for Ozempic 0.25 mg, 0.5 mg, or 1 mg ($499/month for 2 mg). A limited introductory offer of $199/month for new patients on lower doses is available through March 31, 2026. HSA and FSA funds can typically be used for compounded GLP-1 medications.
What Happens After the Intro Price?
MEDVi: Semaglutide injection goes from $179 (Month 1) to $299 (Month 2+). Semaglutide tablets go from $249 (Month 1) to $369 (Month 2+). Tirzepatide injection is listed from $349/mo and tirzepatide tablets from $279/mo for the first month. Multiple independent reviews report that tirzepatide refills increase with dose escalation, potentially reaching $399–$499/mo at maintenance doses. Get your specific refill pricing confirmed in writing during checkout.
TrimRx: The regular monthly rate is $299/mo for semaglutide and $399/mo for tirzepatide, with a limited promotional offer showing $179 and $279 respectively. Multi-month plans lock in lower rates: $174–$209/mo for semaglutide and $283–$316/mo for tirzepatide. Get your plan details confirmed in writing (email or screenshot) before your second billing cycle.
How Do I Cancel?
MEDVi: Cancel by emailing [email protected] or through your online account at least 72 hours before your billing date. MEDVi's refund policy states that "in no event" will a refund be issued once a billing cycle has been charged — so timely cancellation before renewal is essential.
TrimRx: Cancel via online chat or call 888-896-1612. Some Trustpilot and BBB reviewers report difficulty with cancellations, so extra caution is warranted.
Cancellation Best Practices (for Either Provider):
- Cancel in writing, not just by phone. Use chat, email, or your account dashboard.
- Screenshot the confirmation. Save the date, time, and any confirmation number.
- Follow up in 48 hours. Send a brief message confirming your cancellation.
- Set a calendar reminder for your next billing date. Check your credit card statement.
- Know your credit card's chargeback rights. If charged after documented cancellation, contact your credit card company.
What About Side Effects?
GLP-1 medications carry real side effects regardless of whether you get them from MEDVi, TrimRx, or a retail pharmacy with brand-name drugs. According to the Wegovy prescribing label, the most common adverse reactions include:
- Nausea: 44%
- Diarrhea: 30%
- Vomiting: 25%
- Constipation: 24%
Source: Wegovy FDA prescribing label, adult clinical trial data.
These side effects are typically worst during the first 2–4 weeks and after each dose increase. Both providers offer dosage adjustments to manage side effects. See our complete guide: GLP-1 side effect management.
Practical Tips from Reviewers:
- Eat smaller, more frequent meals. Large meals on a GLP-1 medication are a recipe for nausea.
- Stay hydrated. These medications can contribute to dehydration.
- Avoid fatty or greasy foods in the first few weeks.
- Take your injection at bedtime so you sleep through the worst of the initial nausea window.
When to contact your provider immediately: Severe abdominal pain that doesn't resolve, persistent vomiting for more than 24 hours, signs of an allergic reaction (swelling, difficulty breathing), or any sudden change in vision.
Semaglutide vs. Tirzepatide — Which Medication Should I Choose?

Key differences between semaglutide and tirzepatide — based on published clinical trial data.
| Factor | Semaglutide | Tirzepatide |
|---|---|---|
| Avg. Weight Loss | ~15% body weight | Up to ~20.9% (15mg dose) |
| Mechanism | GLP-1 only | GLP-1 + GIP (dual) |
| Time Studied | Longer track record | Newer, less long-term data |
| Side Effect Profile | Similar GI side effects | Similar GI side effects |
| Cost at MEDVi | $179→$299/mo (injection) · $249→$369/mo (tablets) | $349/mo injection · $279/mo tablets |
| Cost at TrimRx (monthly) | $299/mo ($179 promo) | $399/mo ($279 promo) |
If budget is your primary constraint, start with semaglutide. If maximizing weight loss results is your priority and your budget allows, tirzepatide has shown stronger average outcomes. MEDVi's tirzepatide tablets at $279/mo offer the most affordable entry point. If you're unsure, start with semaglutide and assess your response over 3–6 months. Read more: Semaglutide vs Tirzepatide.
What About Oral Wegovy?
The FDA approved an oral formulation of semaglutide (branded as Wegovy) in December 2025. It's a daily pill rather than a weekly injection, and it represents a significant new option for people who prefer not to self-inject. As of early 2026, oral Wegovy is entering the market and pricing is being established. If you have insurance coverage for Wegovy, this may be a preferable option to compounded injectables. Learn more: Wegovy Pill Cost & Where to Buy.
Is MEDVi the Same as MEDvidi?
No. This is a common confusion. MEDVi (medvi.org) is the GLP-1 weight loss provider reviewed on this page. MEDvidi (medvidi.com) is a separate telehealth platform focused on mental health and ADHD treatment. They are different companies offering different services.
Frequently Asked Questions: MEDVi vs TrimRx
Is MEDVi legit?
Yes. MEDVi is LegitScript-certified, has over 11,498 Trustpilot reviews at 4.4/5 stars, uses the OpenLoop Health provider network, and states it works with "multiple USA certified pharmacies." You can independently verify their LegitScript status at LegitScript.com and their Trustpilot reviews at Trustpilot.com/review/medvi.org.
Is TrimRx legit?
TrimRx is an operating telehealth weight loss provider with approximately 635 Trustpilot reviews at ~3.4/5 stars. It is not LegitScript-certified and does not publicly name its compounding pharmacy partners. Its BBB profile shows complaints related to billing discrepancies and cancellation difficulties. TrimRx has both satisfied customers and legitimate concerns — verify pharmacy sourcing and get pricing in writing before committing.
What are the money-back guarantees?
MEDVi's current refund policy states that "in no event" will it issue a refund once a billing cycle has been charged — meaning a standard cancellation does not entitle you to a refund for the current period. To avoid being charged for the next cycle, you must cancel at least 72 hours before your billing date. TrimRx advertises a results guarantee (often framed as 90 days; confirm exact terms in your checkout flow before paying). Both require contacting customer support to initiate a refund request. Document your request in writing and save the confirmation.
Can I switch from TrimRx to MEDVi (or vice versa)?
Yes. There are no exclusivity agreements. If you're switching, let your new provider know what medication and dose you were on so they can manage your transition appropriately. Don't stop GLP-1 medication abruptly and then wait weeks to restart — the gap can cause rebound appetite, and your new provider will likely need to restart you at a lower dose.
Does either provider accept insurance?
No. Both are cash-pay only. If your insurance covers GLP-1 medications, explore Wegovy, Ozempic, Zepbound, or the new oral Wegovy formulation first.
What's the cheapest way to get semaglutide in 2026?
If you have insurance coverage, your copay for Wegovy or Ozempic could be as low as $25–$50/month. If you're paying cash for brand-name, NovoCare's self-pay program offers Ozempic at $349/month for lower doses with a $199/month introductory offer through March 31, 2026. For compounded, TrimRx's 12-month plan at $174/month is the lowest ongoing rate between these two providers. MEDVi's senior discount brings semaglutide to $249/month for 65+. MEDVi also offers semaglutide tablets at $249→$369/month for those who prefer pills over injections.
How fast will I lose weight?
Clinical trial averages provide a baseline: approximately 15% of body weight over 68 weeks with semaglutide (STEP 1) and up to approximately 20.9% over 72 weeks with tirzepatide at the highest dose (SURMOUNT-1). Most people notice appetite reduction within the first 1–2 weeks, scale changes in weeks 2–4, and meaningful visible results by months 2–3.
Do I need a video appointment?
Neither MEDVi nor TrimRx requires video consultations for all patients, though MEDVi's site mentions video visits may be required in some cases (such as before refill prescriptions). Both use questionnaire-based evaluations reviewed by licensed providers. MEDVi offers unlimited 24/7 messaging with your care team.
What if the medication doesn't work for me?
Your options include dosage adjustment, medication switch (semaglutide to tirzepatide or vice versa), and your provider's money-back guarantee if applicable. Approximately 10–15% of patients are considered non-responders to GLP-1 medications. If you've been on an adequate dose for 4+ months with negligible results, discuss alternative approaches with your provider.
Does MEDVi offer senior discounts?
Yes. MEDVi offers $50/month off for patients 65 and older, bringing semaglutide to $249/month and tirzepatide injection to $299/month. TrimRx does not advertise a comparable senior discount as of March 2026.
Can I use GLP-1 medications if I have type 2 diabetes?
Yes — both semaglutide and tirzepatide were originally developed as type 2 diabetes medications. However, if you're already on diabetes medications (especially insulin or sulfonylureas), adding a GLP-1 can increase hypoglycemia risk. List all current medications accurately during intake.
Questions to Ask Any GLP-1 Provider Before You Pay
Copy and paste these directly into the provider's chat or intake form:
About the medication: "What compounding pharmacy fills your prescriptions? Can you provide the pharmacy name and license number?" · "Do you use semaglutide base or a salt form like semaglutide sodium?" · "What is my starting dose and titration schedule?"
About pricing: "What is my price for Month 1 and Month 2+? Are there any dose-based price increases?" · "Are there any additional charges beyond the monthly subscription?" · "Can I get my complete pricing breakdown in writing via email?"
About cancellation: "How do I cancel? Is there a specific deadline?" · "Will I receive written confirmation?" · "What is your refund policy if I cancel mid-cycle?"
Any legitimate provider will answer these without hesitation. If you get vague responses or pressure to "just sign up" — walk away.
5-Minute Legitimacy Check Before You Pay Any GLP-1 Provider
- Check Trustpilot directly. Go to Trustpilot.com and search the provider name. Look at total review count, overall rating, and read recent reviews.
- Search LegitScript. Go to LegitScript.com and search the provider. Certification means third-party verification.
- Ask for the pharmacy name. Any legitimate provider should tell you.
- Verify the pharmacy. Look it up at your state's Board of Pharmacy website and the FDA's Registered Drug Establishments database.
- Screenshot everything. Order total, plan details, cancellation policy.
Your Next-Step Safety Checklist
Before you sign up with either provider, run through this:
- Checked your insurance first. Ask: "Does my plan cover Wegovy, Ozempic, or Zepbound?"
- Verified the provider. Checked Trustpilot and LegitScript.
- Asked for the pharmacy name. Got the compounding pharmacy name and license number. Verified it independently.
- Got pricing in writing. Screenshotted or saved an email confirming Month 1 price, ongoing price, and total monthly cost.
- Understood the guarantee. Know the exact terms.
- Know how to cancel. Found the method and noted deadlines.
- Set a calendar reminder. Marked your next billing date.
- Told your primary care provider. Even with telehealth, your regular doctor should know.
Final Verdict: MEDVi vs TrimRx
After verifying pricing on both checkout pages, analyzing thousands of Trustpilot reviews, checking regulatory compliance, and comparing every meaningful feature, here's where we land.
For most people exploring compounded GLP-1 weight loss medication on a month-to-month basis, MEDVi is the stronger choice. Over 11,498 Trustpilot reviews at 4.4/5 stars, LegitScript certification, no supplement upsells, a hybrid platform adding brand-name Wegovy and Zepbound options, senior discounts, and the lowest tirzepatide entry point ($279/mo tablets) create a trust and value profile that TrimRx hasn't matched.
TrimRx earns genuine consideration if you're ready to commit long-term. Their 6-month semaglutide plan at $191/mo and 12-month at $174/mo represent significant savings over MEDVi's $299/mo refill rate — potentially $1,500/year. If you know you're staying on semaglutide for 6+ months and you're comfortable with the upfront commitment, TrimRx's pricing advantage is real.
Neither is perfect. Both provide compounded medications that aren't FDA-approved. Both operate in a post-shortage regulatory environment. Both carry real side effects. Neither guarantees results.
The biggest risk isn't choosing the wrong provider — it's not starting at all. A good plan you execute today beats a perfect plan you research forever. Pick the one that fits your situation, protect yourself with the checklist above, and take the first step.
Not ready yet? That's okay. Bookmark this page. We update pricing and reviews monthly, so the data will be current whenever you come back. Explore more comparisons: MEDVi vs Hers, MEDVi vs Ro, MEDVi vs Remedy Meds. Or visit our learning center for more GLP-1 education.
About the WPG Research Team
This article was researched and written by the WPG Research Team. Our editorial process: we verify all pricing by visiting provider checkout pages directly (never relying on press releases or affiliate networks), cross-reference clinical claims against peer-reviewed trials published in the New England Journal of Medicine and JAMA, check regulatory status through FDA.gov databases and enforcement records, and analyze review patterns across Trustpilot and the BBB. We re-verify all data points monthly and update this page when prices, policies, or regulatory conditions change. We do not provide medical advice — our goal is to help readers make informed decisions using verified, primary-source data.
Sources
- MEDVi.org — Official website, pricing and program details (verified March 30, 2026)
- TrimRx checkout page — Pricing and plan details (verified March 30, 2026)
- Trustpilot — MEDVi Reviews (11,498 reviews, 4.4/5 average, verified March 30, 2026)
- Trustpilot — TrimRx Reviews (~635 reviews, ~3.4/5 average)
- Wilding JPH, Batterham RL, Calanna S, et al. "Once-Weekly Semaglutide in Adults with Overweight or Obesity." New England Journal of Medicine. 2021;384(11):989-1002. doi:10.1056/NEJMoa2032183
- Jastreboff AM, Aronne LJ, Ahmad NN, et al. "Tirzepatide Once Weekly for the Treatment of Obesity." New England Journal of Medicine. 2022;387(3):205-216. doi:10.1056/NEJMoa2206038
- FDA.gov — FDA's Concerns About Unapproved GLP-1 Drugs Used for Weight Loss
- FDA.gov — Semaglutide Safety Information
- FDA — Wegovy (semaglutide) prescribing information
- FDA — Zepbound (tirzepatide) prescribing information
- FDA Warning Letters Database
- LegitScript.com — Telehealth certification verification
- Wilding JPH, Batterham RL, Davies M, et al. "Weight regain and cardiometabolic effects after withdrawal of semaglutide: The STEP 1 trial extension." Diabetes, Obesity and Metabolism. 2022;24(8):1553-1564.
- Weight Loss Provider Guide — Is Compounded Semaglutide Safe?
- Weight Loss Provider Guide — MEDVi vs Hers Comparison
- Weight Loss Provider Guide — MEDVi vs Ro Comparison
- Weight Loss Provider Guide — MEDVi vs Remedy Meds Comparison
- FDA.gov — FDA Intends to Take Action Against Non-FDA-Approved GLP-1 Drugs
- r/semaglutide — Community discussions on semaglutide providers
- r/tirzepatide — Community discussions on tirzepatide providers
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