MedVi vs MyStart GLP-1: Which Program Is Actually Better for You?
If you're comparing MedVi vs MyStart right now, you're trying to answer a straightforward question before you spend real money: which GLP-1 program is cheaper after month one, which one is more transparent, and which one is less likely to surprise you?
We've spent considerable time digging through official pricing pages, terms of service, refund policies, pharmacy disclosures, and real patient reviews for both providers. Here's the fast answer:
Both are legitimate, LegitScript-certified providers — but they're built for different priorities. MedVi has the lowest semaglutide entry price ($179 first month), includes free shipping and lab work when medically necessary, partners with established U.S. compounding pharmacies (including Belmar Pharma Solutions, per third-party reviews), offers both injectable and oral tablet options, and carries a 4.5-star Trustpilot rating from over 10,700 reviews. If price and flexibility are your top priorities, MedVi is the stronger option.
MyStart has a genuinely valuable differentiator: a price-lock guarantee that means your base rate won't increase as your dose goes up. Over 6–12 months on tirzepatide, that can save real money. They also have 600+ board-certified doctors and a named Chief Medical Advisor. If long-term cost predictability is your priority, MyStart deserves serious consideration.
But there's a lot more to it than intro pricing, and the details matter when you're paying $200–$500 a month out of pocket with no insurance safety net. Below, we break down everything: real pricing after the intro discount, what's actually included, pharmacy quality, cancellation terms, side effects, state availability, and every edge case we could find — so you can decide with confidence and stop searching.
Disclosure: Some links on this site are affiliate links. If you purchase through these links, we may earn a commission at no extra cost to you. Thank you for supporting our site.·For informational purposes only—not medical advice.
For informational purposes only—not medical advice.
Ready now?
5-minute assessment. If their medical provider determines you don't qualify, you receive a full refund per MedVi's published policy.
Check If You Qualify with MedVi →Want the full breakdown first? Keep reading.
How Do MedVi and MyStart Actually Compare?
We verified every data point below from each provider's official website, public policy pages, and third-party review platforms. All pricing is provider-stated as of March 2026 — always verify current rates at checkout before enrolling.
| Category | MedVi | MyStart |
|---|---|---|
| Semaglutide injection — first month | $179 (introductory) | $299/mo base program (promotional pricing varies by landing page) |
| Semaglutide injection — ongoing | $299/mo | $299/mo (price locked at your base rate) |
| Semaglutide — multi-month plan | Month-to-month only | 3-month plans available at lower per-month rates (verify at checkout) |
| Tirzepatide injection — first month | $279–$349 (introductory, varies by formulation) | $279 (promotional — verify base rate at checkout) |
| Tirzepatide injection — ongoing | $399–$499/mo (per ConsumerAffairs; dose-dependent) | Price locked at your base rate (verify locked amount at checkout) |
| Oral tablet options | ✅ Semaglutide + tirzepatide | Not prominently offered |
| Price-lock guarantee | ❌ Price may increase with dose | ✅ Base rate locked — won't increase with dose increases |
| Membership fees | $0 | $0 |
| What's included | Consultation, medication, shipping, labs (when needed), 24/7 messaging, doctor-led coaching, unlimited provider access | Consultation, medication, shipping, blood work, clinician access as often as needed |
| Insurance | No — cash pay (HSA/FSA accepted) | No — cash pay (HSA/FSA documentation support) |
| Compounding pharmacy | Belmar Pharma Solutions and other licensed U.S. pharmacies (per ConsumerAffairs, March 2026) | Licensed U.S. 503A pharmacies (not publicly named) |
| LegitScript certified | ✅ | ✅ |
| Trustpilot rating (March 2026) | 4.5/5 from 10,700+ reviews | ~4.1/5 from 280+ reviews |
| Money-back guarantee | 5-month weight-loss guarantee (minus 25% consultation fee); full refund if medically disqualified | Full refund if medically ineligible or if you cancel before fulfillment; once shipped, no refund |
| State availability | Available in most U.S. states; some states require live consultation (verify during intake) | Nationwide (state-specific regulations may apply) |
| Brand-name options | ✅ Ozempic/Wegovy available ($1,999/mo) | Wegovy and Ozempic listed on some pages, though legal disclosures state MyStart does not offer brand-name products — verify directly |
| Cancellation | Cancel anytime (72-hr notice before billing date) | Cancel anytime (email or call) |
| Founded | 2023 (San Diego, CA / Newark, DE) | 2022 (Newark, DE) |
Important: MyStart shows different prices on different landing pages ($179, $279, $299 depending on the page and plan). Their FAQ states the program starts at $299/month excluding discounts. Always confirm your exact checkout price. MedVi's tirzepatide pricing increases as your dose escalates — ask for a full cost projection before you start.
The table shows you what each platform offers. The next section helps you figure out which one matches your situation.
Should I Choose MedVi or MyStart? Here's How to Decide
We'll keep this simple. There are really only a few variables that matter.
Choose MedVi if any of these sound like you
You want the lowest barrier to entry.
MedVi's semaglutide program starts at $179 for the first month. No membership fees, no hidden charges, no multi-month commitment required. You pay month-to-month and can cancel anytime. For someone testing the waters with GLP-1 medication for the first time, that's about as low-risk as it gets in this space.
You'd rather take a daily tablet than a weekly injection.
This is a bigger deal than most comparison articles mention. MedVi offers compounded oral tablets for both semaglutide and tirzepatide. MyStart's programs are primarily injection-based. If needles make you queasy — or you just prefer swallowing a pill — MedVi is one of the few telehealth GLP-1 providers offering that flexibility.
Pharmacy transparency matters to you.
According to third-party reviews including ConsumerAffairs (updated March 2026) and the Vaccine Alliance, MedVi partners with Belmar Pharma Solutions — a compounding pharmacy that's been operating since 1985 with six facilities across the United States. They follow USP compounding standards and perform independent third-party testing. MyStart works with licensed U.S. pharmacies but doesn't publicly name them — which isn't necessarily a red flag, but it's less verifiable.
You want a massive review base as a trust signal.
MedVi has over 10,700 Trustpilot reviews with a 4.5/5 rating as of March 2026. MyStart has around 280 at ~4.1/5. Both are positive overall, but MedVi's review base is roughly 38 times larger. When you're spending hundreds of dollars a month on a health product, that volume of feedback is reassuring.
You might want brand-name medication down the line.
MedVi prescribes FDA-approved Ozempic and Wegovy (at $1,999/month — expensive, but the option exists). If you want the flexibility to switch to brand-name under the same provider relationship, MedVi gives you that path.
You value all-in simplicity.
Free shipping. Lab work when medically necessary — included. 24/7 messaging with providers. Doctor-led care coaching. Unlimited telehealth visits. That's all included in MedVi's monthly price with no add-on charges.
“Lost 16 lbs in 10 weeks — no side effects. Down two sizes. I wish I’d started sooner.”
— Verified MEDVi patient on ConsumerAffairs ★★★★★
Choose MyStart if this specific factor is your top priority
Long-term price predictability is your number-one concern.
MyStart's price-lock guarantee is their signature feature, and it's a real differentiator. Here's how it works: the base monthly rate you lock in at enrollment stays the same even if your doctor increases your dose over time. That matters because dose escalation is normal — most patients start on a lower dose and titrate up over several months. With MedVi, tirzepatide pricing goes up as your dose goes up (potentially reaching $499/month at higher doses, per ConsumerAffairs). With MyStart's price lock, your rate stays put.
If you're planning to use tirzepatide for 6–12 months and you're confident in committing to a multi-month upfront payment, MyStart's pricing structure could save you real money at higher doses.
A couple things to know: The price-lock excludes introductory/promotional discounts (your locked rate is the post-promo base, not the first-month deal). And the multi-month plans require upfront payment. Confirm the exact locked rate at checkout before you enter your card info.
The factor most people overlook: total cost over 12 months
Month-one pricing is marketing. What actually matters is what you'll pay over six to twelve months. Let's walk through the math.
Semaglutide, 12-month estimate:
- • MedVi: $179 (month 1) + $299 × 11 months = ~$3,468/year
- • MyStart (base rate): $299/month × 12 = ~$3,588/year (with price lock)
- • MyStart (promotional): Potentially lower — verify exact plan pricing at checkout
Tirzepatide, 12-month estimate:
- • MedVi: $279–$349 (month 1) + escalating to $399–$499/mo = ~$4,700–$5,800/year
- • MyStart (price-locked): Potentially significantly lower at higher doses — verify locked rate at checkout
Our take:
For semaglutide — which is where most beginners start — MedVi's included labs, oral tablet options, pharmacy transparency, and massive review base make it the better total value, even when the raw annual cost is similar. For tirzepatide at higher doses, the price-lock becomes a real advantage for MyStart — but only if you're committing to upfront multi-month payments and you're comfortable with the less transparent pharmacy situation.
Note: These are estimates based on publicly listed rates as of March 2026. Pricing changes. Always verify directly before enrolling.
MedVi: The Full Breakdown
Let's go deep on what you're actually getting.
How MedVi works, step by step
- Complete an online health questionnaire. Takes about 5 minutes. Covers your medical history, current medications, weight-loss goals, and contact info.
- A licensed clinician reviews your information. MedVi works with OpenLoop Health, a network of U.S.-licensed doctors. They review your intake and decide whether GLP-1 therapy is appropriate for you. In most states, this can happen without a video call. Some states require a live consultation before prescribing due to local telehealth laws — you'll be informed during intake if this applies to you.
- If approved, your prescription is sent to a compounding pharmacy. MedVi partners with licensed U.S. compounding pharmacies including Belmar Pharma Solutions (per ConsumerAffairs, March 2026). Your medication is prepared, packed with temperature-controlled shipping, and sent directly to your door.
- You start your medication and get ongoing support. 24/7 messaging with your care team. Doctor-led care coaching. Unlimited telehealth visits. Dose adjustments as needed. Lab work when medically necessary — included in your monthly cost.
- Refill on your billing cycle. MedVi operates on a 28-day billing cycle. Your medication ships before each new cycle so you don't run out.
What MedVi costs — the real numbers
Here's the full pricing picture, not just the intro rate:
- Compounded semaglutide injections: $179 first month → $299/month ongoing
- Compounded semaglutide tablets: $249 first month → $369/month ongoing
- Compounded tirzepatide injections: $279–$349 first month → $399–$499/month ongoing (dose-dependent, per ConsumerAffairs)
- Compounded tirzepatide tablets: $279 first month → $399/month ongoing
- Brand-name Ozempic/Wegovy: $1,999/month (available but expensive)
Everything is included in the monthly price: clinician evaluation, personalized treatment plan, medication supply, shipping, lab work when needed, doctor-led coaching, and unlimited messaging and telehealth support. No membership fees. No hidden charges. HSA and FSA cards are accepted.
About the compounding pharmacy behind MedVi
This is worth knowing because who makes your medication matters. According to ConsumerAffairs (updated March 13, 2026) and the Vaccine Alliance, MedVi partners with Belmar Pharma Solutions. Belmar has been compounding medications since 1985 — that's 40 years of experience, well before the GLP-1 telehealth boom. They operate six 503A sterile and non-sterile compounding facilities across the United States, follow USP compounding standards, and perform continuous independent testing of ingredients and finished compounds.
MedVi's own website states they are “partnered with multiple USA certified pharmacies” and that their team “meets regularly with pharmacies to discuss any product shortages, shipping delays, and get updated reports on their medication testing.”
That combination of a named, established pharmacy partner and public quality commitments is uncommon in the telehealth GLP-1 space, where many providers don't disclose their pharmacy partners at all.
Important disclosure: Compounded medications are prepared by licensed pharmacies in FDA-regulated facilities but are not FDA-approved as finished products. MedVi discloses this clearly on their website. This is standard across the entire compounded GLP-1 industry — it applies to every telehealth provider, not just MedVi. If you want FDA-approved medication, MedVi also offers brand-name Wegovy and Ozempic (at a significantly higher price point).
What makes MedVi stand out
- Oral tablets for both semaglutide and tirzepatide — one of very few telehealth GLP-1 providers offering this
- Named, established pharmacy partner — Belmar has been operating since 1985 (per third-party reviews)
- 10,700+ Trustpilot reviews at 4.5/5 as of March 2026
- All-inclusive pricing — labs, shipping, provider access, doctor-led coaching, and medication all in one monthly fee
- LegitScript certified — independently monitored for compliance
- 5-month weight-loss guarantee — if you follow the program and don't lose weight, you may qualify for a refund (minus 25% consultation fee)
- Brand-name options available — switch to FDA-approved Ozempic or Wegovy within MedVi
- MedVi Meals — optional chef-prepared, medically aligned meal delivery service for GLP-1 patients
What to know before you sign up
No provider is perfect, and we'd rather you go in with eyes open:
- Cancel at least 72 hours before your billing date to avoid being charged for the next cycle.
- Refund limitations after medication is ordered. MedVi's policy states: “Other than cancellation due to medical disqualification, in no event shall you be issued a refund upon cancellation.” If you're disqualified by a medical provider, you receive a full refund.
- Tirzepatide pricing increases with dose. If you start at $279, expect to pay $399–$499 at higher maintenance doses. Ask your provider for a full dosing/pricing schedule upfront.
- Medication-focused, not a full lifestyle program. MedVi provides clinical guidance, dose management, doctor-led coaching, and nutrition support. But it's not a structured behavioral weight-loss curriculum.
Ready to check your eligibility?
Choose between semaglutide or tirzepatide. Pick injection or oral tablet. See your pricing. A licensed provider reviews your health info and determines if you qualify. The assessment takes about 5 minutes.
Start Your MedVi Assessment →Full refund if medically disqualified. No contract.
MyStart Health: The Full Breakdown
MyStart deserves a fair and thorough look. Here's what they offer and where they shine.
How MyStart works, step by step
- Complete a health intake questionnaire online. Similar to MedVi — covers medical history, current medications, and weight-loss goals.
- Pre-screening determines initial eligibility. Payment is processed after pre-qualification and medication preference selection.
- Telehealth consultation with a licensed provider. MyStart works with a network of 600+ board-certified U.S. doctors. Your provider makes the final prescribing decision independently.
- Medication is compounded and shipped. MyStart works with licensed U.S. 503A compounding pharmacies. Medication is shipped with refrigerated packaging. Shipping typically takes 2–4 business days after prescription.
- Ongoing care and refills. Access to clinicians at no additional cost as often as you need. Dose adjustments as needed.
What MyStart costs — the real numbers
Here's where it gets a little complicated. MyStart shows different prices depending on which landing page you're on.
Official base program price (per FAQ): $299/month, excluding any discounts. This covers physician evaluations, follow-up appointments, unlimited clinician access, prescriptions, medication supply, blood work as needed, and shipping.
Promotional pricing (varies by landing page and plan): We've seen semaglutide offers as low as ~$179 and tirzepatide starting at $279 on various MyStart pages. Multi-month plans may offer lower per-month rates when paid upfront. Always confirm your exact price and plan terms at checkout.
No membership fees. All-inclusive pricing.
The price-lock guarantee explained:
Once you enroll, your base monthly rate does not increase — even when your doctor increases your dose. This is MyStart's biggest selling point. However, the lock excludes promotional discounts offered during initial enrollment. Your locked rate is the post-promo base, not the intro deal. Confirm the exact locked amount at checkout.
What MyStart does well
- Price-lock guarantee — genuinely valuable for patients facing dose escalation costs over 6–12 months
- Large doctor network — 600+ board-certified U.S. physicians
- Named Chief Medical Officer — Dr. Ritu Chopra, a Beverly Hills-based surgeon, serves as Chief Medical Advisor
- All-inclusive pricing — similar to MedVi, everything is bundled into the monthly fee
- LegitScript certified — same independent compliance monitoring
What to know before you sign up
- Pharmacy partner not publicly named. You won't know which pharmacy compounds your medication until after enrollment. You can ask directly during intake.
- Smaller Trustpilot presence. Around 280 reviews at ~4.1/5. Some reviews mention shipping delays and customer service inconsistencies. The CEO (Matthew Stern) has personally responded to negative reviews — a positive sign.
- Multi-month upfront payment for best pricing. The lowest per-month rates require paying for multiple months upfront.
- No oral tablet options prominently offered. If you prefer tablets over injections, MedVi is currently the better fit.
- Refund policy after shipment. Once an order has shipped, it cannot be canceled and no refund is issued.
- Brand-name availability is unclear. Some pages list Wegovy ($1,600) and Ozempic ($1,899), while the legal disclosure states MyStart does not offer brand-name products. Verify directly.
- Outcome claims need context. MyStart reports a 92% patient success rate and an average of 22 lbs lost in 6 months — from a survey of 16 MyStart Health customers (per their own disclosure). Encouraging but not independently verified.
What Happens After You Sign Up? The Full Timeline
Understanding the process from signup to medication-in-hand removes a lot of anxiety. Here's what to expect.
MedVi: signup to medication at your door
- Day 1: Complete the online health questionnaire (~5 minutes). Choose between semaglutide or tirzepatide, and between injection or oral tablet.
- Day 1–2: A licensed clinician from the OpenLoop Health network reviews your information. Some states require a live consultation.
- Day 2–3: If approved, your clinician creates a personalized treatment plan. Your prescription is sent to a partner compounding pharmacy.
- Day 3–7+ (first order): The pharmacy compounds your medication, packages it with temperature-controlled shipping, and delivers it. First orders may take a bit longer; refills are typically faster.
- Ongoing: Membership renews every 28 days. 24/7 messaging access, doctor-led coaching, telehealth visits as often as needed. Follow-up labs included when medically necessary.
MyStart: signup to medication at your door
- Day 1: Complete the health intake questionnaire. Pre-screening determines eligibility. Select medication preference and plan length.
- Day 1–2: Payment processed after pre-qualification. A licensed clinician from MyStart's 600+ doctor network reviews your information.
- Day 2–4: If approved, your prescription goes to a licensed U.S. compounding pharmacy.
- Day 4–7: Medication ships within 2–4 business days after the prescription is issued.
- Ongoing: Clinician access at no additional cost as often as needed. Dose adjustments managed by your provider.
Side-by-side timeline
| Stage | MedVi | MyStart |
|---|---|---|
| Intake questionnaire | ~5 minutes | ~5 minutes |
| Clinician review | 1–2 days | 1–2 days |
| Pharmacy fulfillment | Varies (first order may take longer) | 2–4 business days after Rx (per FAQ) |
| Refill cadence | Every 28 days (auto) | Monthly or multi-month |
| Support access | 24/7 messaging + coaching + unlimited visits | Clinician access as needed |
What to expect physically in the first few weeks: Most patients notice reduced appetite within the first week or two. Nausea is the most common early side effect — it usually settles down as your body adjusts. Drink plenty of water, eat smaller meals, and prioritize protein. Your provider can help you manage side effects and will adjust your dose if needed. Both MedVi and MyStart provide ongoing clinical support for exactly this purpose.
Dose escalation matters more than you think.
Most GLP-1 patients start at a low dose and titrate up over several months to reach their therapeutic dose. This is normal. But here's the thing most comparison sites don't mention: with MedVi, dose increases on tirzepatide may increase your monthly cost. With MyStart's price lock, your rate stays the same through dose increases. If you're choosing between providers, this is one of the most important factors to think about — especially if you expect to be on tirzepatide for 6+ months.
What Happens After Month One? The Real Cost Question Nobody Else Answers
This is the section that matters most — and the one every other comparison page skips.
Month-one pricing is a marketing tool. Every GLP-1 telehealth provider leads with their best introductory number. The real question is: what are you actually going to spend over the next 6 to 12 months?
MedVi: month-to-month, pricing may increase with dose
MedVi's model is straightforward: your monthly fee covers everything, and you pay month-to-month with no contract. However, if you're on tirzepatide and your doctor increases your dose, your monthly cost may increase. Semaglutide pricing appears stable at $299/month after the intro period. What you can count on: no membership fees, no shipping charges, no lab fees. The only variable is the medication cost itself based on your dose and formulation.
MyStart: upfront commitment, but the rate is locked
MyStart's model rewards commitment. Pay upfront for multiple months and lock in a rate that stays constant even through dose increases. The trade-off is the initial lump payment and the refund limitations — once medication ships, no refund is available per their published policy.
The math, plain and simple
| Scenario | MedVi (12-month est.) | MyStart (12-month est.) |
|---|---|---|
| Semaglutide injections | ~$3,468 ($179 + 11×$299) | ~$3,588 at base rate ($299×12, price locked) |
| Tirzepatide injections | ~$4,700–$5,800 (dose escalation) | Potentially lower with price lock — verify locked rate |
Our take:
For semaglutide — which is where most beginners start — MedVi's included labs, oral tablet options, pharmacy transparency, and 10,700+ reviews make it the better total value. For tirzepatide at higher doses, MyStart's price lock becomes a real financial advantage — but only if you're committing to multi-month upfront payments and you're comfortable with the unnamed pharmacy situation.
What to verify at checkout (for either provider)
- Confirm the exact medication type and formulation. Are you getting semaglutide or tirzepatide? Injection or tablet?
- Confirm your starting dose and the expected titration schedule. Ask: “How many dose increases will I need, and how will each one affect my cost?”
- Confirm whether the price shown is promotional or your ongoing base rate. Especially important with MyStart.
- Confirm the refill cadence and your next billing date. MedVi bills every 28 days. MyStart varies by plan.
- Confirm the cancellation deadline. MedVi requires 72 hours before billing. Mark your calendar.
- Read the refund policy. Not skim it — read it. Know what's refundable and when.
- Ask about the pharmacy. Who compounds your medication? What testing do they perform?
How Hard Is It to Cancel or Get a Refund?
Nobody likes to think about canceling before they've even started, but smart buyers always check the exit before walking through the door.
MedVi's cancellation and refund terms
- • Cancel anytime — no long-term contract. Email [email protected], use the chat feature in your patient portal, or call (323) 690-1564.
- • 72-hour notice required — submit your cancellation at least 72 hours before your next billing date.
- • Refunds after cancellation: “Other than cancellation due to medical disqualification, in no event shall you be issued a refund upon cancellation.”
- • Medical disqualification: Full refund if MedVi's clinician determines you don't qualify.
- • 5-month weight-loss guarantee: If you follow the program as directed for five months and haven't lost weight, you may qualify for a refund minus a 25% consultation fee.
MyStart's cancellation and refund terms
- • Cancel anytime — email [email protected] with “CANCEL” in the subject line, or call 833-694-0780.
- • Refund if medically ineligible: Full refund if a licensed provider determines you don't qualify and no prescription was written/shipped.
- • Refund before fulfillment: If you cancel before your medication is prepared and shipped, a full refund applies.
- • After medication ships: No refund under any circumstances, per MyStart's published refund policy.
What this means in plain English
MedVi is easier to start (low entry price, month-to-month) and reasonably easy to cancel — just hit the 72-hour window. The refund policy is tight once medication is ordered, but the 5-month weight-loss guarantee provides a safety net for committed users. And if you don't qualify medically, you get your money back.
MyStart offers a refund window before fulfillment, and a refund if you're medically ineligible. But once medication ships, you're locked in for that cycle. The multi-month upfront plans mean more money at risk if you want out early.
Bottom line: Neither provider will make it difficult to cancel your subscription. The nuance is in refund timing — how much money you can recover and when. Read the policies before you pay.
Are These Programs Legitimate? What You Need to Know About Safety
You're considering sending hundreds of dollars to a telehealth company for medication that'll be shipped to your house. Here's how to know you're dealing with a legitimate operation.
What makes a GLP-1 telehealth provider trustworthy
Look for these signals (both MedVi and MyStart check these boxes):
- Licensed clinicians make the prescribing decision — not an algorithm, not a chatbot.
- Compounding pharmacy is state-licensed and follows USP standards.
- LegitScript certification — independent compliance monitoring.
- Clear disclosure that compounded medications are not FDA-approved.
- Published refund and cancellation policies — you can read them before signing up.
MedVi's credibility signals
- • OpenLoop Health clinician network
- • Compounding pharmacy partners including Belmar Pharma Solutions (per ConsumerAffairs, March 2026)
- • MedVi states compounded GLP-1s are “produced in FDA-regulated facilities” but are “not FDA-approved”
- • LegitScript certified
- • 10,700+ Trustpilot reviews (4.5/5)
- • ConsumerAffairs profile with verified reviews
MyStart's credibility signals
- • 600+ board-certified U.S. doctors
- • Named Chief Medical Advisor (Dr. Ritu Chopra)
- • LegitScript certified
- • Licensed U.S. 503A compounding pharmacies
- • Clear “not FDA-approved” disclosures
- • CEO actively responds to Trustpilot reviews
The compounded medication reality
Both MedVi and MyStart primarily offer compounded GLP-1 medications. Compounded medications are custom-prepared by licensed pharmacies. They are dispensed under a prescription from a licensed provider. They are produced in FDA-regulated facilities. However, compounded medications are not FDA-approved as finished products. They haven't undergone the same premarket review process as brand-name drugs like Wegovy or Zepbound. Both MedVi and MyStart disclose this clearly.
What you should do: Make sure your medication comes from a licensed, USP-compliant pharmacy. Inspect your medication when it arrives — it should be properly refrigerated (for injectables), clearly labeled, and consistent with your prescription. If you want the most regulated path, FDA-approved brand-name medications are available — MedVi offers Ozempic and Wegovy at $1,999/month.
Semaglutide or Tirzepatide — Which Medication Should You Ask About?
This question comes up constantly, and it affects which provider makes more sense for you.
Semaglutide (the ingredient in Wegovy and Ozempic)
Semaglutide works on GLP-1 receptors to help regulate appetite, slow gastric emptying, and support blood sugar control. In the STEP 1 trial, patients using FDA-approved semaglutide (Wegovy 2.4 mg) alongside diet and exercise saw an average body weight reduction of about 14.9% over 68 weeks.
Best for: People new to GLP-1 therapy, moderate weight-loss goals, most affordable entry point. Available through both MedVi and MyStart as compounded injections. MedVi also offers compounded oral semaglutide tablets.
Tirzepatide (the ingredient in Zepbound and Mounjaro)
Tirzepatide targets both GLP-1 and GIP receptors — a dual-action approach. In the SURMOUNT-1 trial, participants saw average body weight reductions ranging from about 16% to 22.5% at 72 weeks depending on dose.
Best for: More aggressive weight-loss goals, patients who've tried semaglutide without sufficient results, people with type 2 diabetes. Available through both MedVi and MyStart — but cost is higher. This is where MyStart's price-lock becomes particularly relevant for long-term use.
A common approach:
Start with semaglutide (lower cost, well-studied) and discuss switching to tirzepatide with your clinician if results plateau. Whether switching is available depends on your provider and clinical situation — always discuss with your prescribing clinician.
Sources: STEP 1 trial (NEJM 2021); SURMOUNT-1 trial (NEJM 2022). Note: These trial results reflect FDA-approved brand-name formulations with specific dosing protocols. Compounded formulations have not undergone the same premarket review.
Can I Use Insurance, HSA, or FSA?
Short answer: no insurance, but HSA/FSA likely works.
Insurance
Neither MedVi nor MyStart accepts insurance. Both operate on a cash-pay, out-of-network model. You're responsible for 100% of program costs. Medicare and Medicaid are not accepted. If insurance coverage is critical to your decision, explore options through your primary care physician, an endocrinologist, or manufacturer programs like LillyDirect or NovoCare.
HSA / FSA
Both MedVi and MyStart accept HSA and FSA cards. Under IRS guidelines, prescription medications ordered by licensed providers are generally eligible expenses. MyStart also provides HSA/FSA documentation support.
Important: Final HSA/FSA eligibility depends on your specific plan administrator. Confirm with your plan before using these funds.
What About State Availability?
MedVi
According to ConsumerAffairs (updated March 2026), MedVi is available in 49 states — all except North Dakota. Some states require a live provider consultation before prescribing due to local telehealth regulations. You'll confirm availability during intake.
MyStart
Available nationwide, though state-specific telehealth regulations may require video consultations in some states. Verify during intake.
What Side Effects Are Typical of GLP-1 Medications?
GLP-1 medications have a well-documented side-effect profile. The medication class drives the core side effects — not the platform you get it from.
Common side effects (especially during early weeks and dose increases)
- • Nausea (the most frequently reported)
- • Vomiting
- • Diarrhea or constipation
- • Stomach pain or discomfort
- • Headache
- • Fatigue
These typically improve within 2–4 weeks as your body adjusts. Starting at a lower dose and titrating up slowly minimizes the intensity. Both providers recommend this approach. Read our GLP-1 diet plan for managing side effects through nutrition.
Less common but serious (seek medical attention)
- • Signs of pancreatitis (severe abdominal pain that won't go away)
- • Gallbladder problems
- • Kidney issues
- • Allergic reactions
Important safety warnings
FDA-approved semaglutide (Wegovy) and tirzepatide (Zepbound) carry boxed warnings about thyroid C-cell tumors based on animal studies. They should not be used by people with a personal or family history of medullary thyroid carcinoma or Multiple Endocrine Neoplasia syndrome type 2 (MEN 2). Both MedVi and MyStart screen for these contraindications during the medical evaluation. Be honest and thorough when filling out your health questionnaire — it exists to protect you.
Who Should NOT Start an Online GLP-1 Program Right Now?
Not everyone is a good candidate for GLP-1 therapy, and responsible providers will screen for these situations.
Pregnancy or plans to conceive.
GLP-1 medications are not recommended during pregnancy. Wegovy's prescribing information advises stopping the medication at least 2 months before a planned pregnancy.
Personal or family history of medullary thyroid carcinoma (MTC) or MEN 2.
This is a contraindication for all GLP-1 receptor agonist medications.
History of pancreatitis.
GLP-1 medications have been associated with pancreatitis in rare cases. Your clinician needs to know about this.
Severe gastrointestinal disease.
GLP-1s slow gastric emptying, which can worsen certain GI conditions. Be thorough about your GI history during the intake questionnaire.
Major medication interactions.
Certain medications can interact with GLP-1 therapy. Disclose every medication, supplement, and OTC product you're taking.
Active eating disorder.
GLP-1 medications significantly affect appetite regulation. These medications should only be used under close supervision if you're managing an active eating disorder.
Under 18.
Both programs are designed for adults.
If any of these apply to you, talk to your primary care physician before enrolling in any online GLP-1 program. A good provider will tell you the same thing during the screening process — but it's better to know upfront.
What Happens If I Want to Stop Treatment? Will I Regain the Weight?
This is a question people don't ask until they're three months in — and by then it feels urgent. Better to address it now.
The regain reality
Clinical data on FDA-approved GLP-1 medications shows that weight regain after stopping treatment is common. In the STEP 1 trial extension, participants who discontinued semaglutide regained a significant portion of the weight they'd lost within a year. This isn't unique to any particular provider — it's how the medication class works.
GLP-1 medications work by regulating appetite, slowing gastric emptying, and affecting the brain's hunger and reward centers. When you stop the medication, those biological signals return to baseline. Without the medication's support, many people find their appetite and cravings gradually return.
What this means for your decision
This isn't a reason to avoid starting. It's a reason to plan ahead. Think about GLP-1 therapy as a long-term tool, not a short-term fix. Many clinicians recommend at least 12 months of treatment to establish new eating patterns and reach a stable weight. After that, some patients maintain on a lower “maintenance dose” rather than stopping entirely.
Both MedVi and MyStart support ongoing treatment. Neither requires a contract, so you can continue as long as the medication is working for you. MedVi's month-to-month model makes it particularly easy to continue without a big upfront commitment.
Have a conversation with your provider about your exit strategy before you start. Ask: “What's the plan when I reach my goal weight? Can I maintain on a lower dose? What lifestyle changes should I be building now so I'm prepared?” The best outcome isn't just losing the weight — it's building the habits and support system that help you keep it off.
How We Researched This Comparison
What we reviewed
- Official websites and pricing pages for both MedVi (home.medvi.org, medvi.io) and MyStart (mystarthealth.com, call.mystarthealth.com)
- Published terms of service, refund policies, and cancellation policies for both providers
- Trustpilot review profiles (10,700+ for MedVi; 280+ for MyStart) as of March 2026
- ConsumerAffairs reviews for MedVi (updated March 13, 2026)
- Belmar Pharma Solutions official website
- FDA guidance on compounded medications
- STEP 1 trial data for semaglutide (New England Journal of Medicine, 2021)
- SURMOUNT-1 trial data for tirzepatide (New England Journal of Medicine, 2022)
- LegitScript certification database
- Multiple third-party editorial reviews
Our scoring framework
| Category | Weight | MedVi | MyStart |
|---|---|---|---|
| Price transparency | 20% | Strong — clear pricing, attributable pharmacy | Good — but variable landing page pricing |
| Long-term cost predictability | 15% | Moderate — tirzepatide increases with dose | Strong — price-lock guarantee |
| Included support and features | 20% | Strong — labs, shipping, 24/7 messaging, coaching, tablets | Good — inclusive, but fewer format options |
| Trust signals (reviews, certification) | 15% | Very strong — 10,700+ reviews, named pharmacy | Moderate — 280+ reviews, unnamed pharmacy |
| Cancellation and refund terms | 10% | Good — month-to-month, 72-hr cancel, 5-mo guarantee | Good — refund before fulfillment, but tight after ship |
| Safety and regulatory transparency | 10% | Strong — clear disclosures, named pharmacy | Good — clear disclosures, pharmacy unnamed |
| HSA/FSA and payment flexibility | 10% | Good — accepted | Good — accepted with documentation support |
Our overall assessment: MedVi is the stronger fit for most first-time GLP-1 users. MyStart is the stronger fit for long-term tirzepatide patients who prioritize cost predictability.
What If Neither MedVi Nor MyStart Is the Right Fit?
If you want FDA-approved brand-name medication at a lower price
Look into manufacturer programs directly. LillyDirect offers Zepbound single-dose vials starting at $299/month for the 2.5 mg dose and $399–$449/month for higher doses. NovoCare offers savings programs for Wegovy. Your primary care physician can also prescribe brand-name GLP-1 medications and help navigate insurance.
If you want a full coaching and lifestyle program
Both MedVi and MyStart include medical support, and MedVi's public pages mention doctor-led care coaching and nutrition support. However, neither reads like a standalone behavioral weight-loss curriculum. If you want intensive, structured coaching alongside medication, some telehealth programs pair GLP-1 therapy with more structured behavioral support.
Explore our other guides:
Frequently Asked Questions: MedVi vs MyStart
Is MedVi cheaper than MyStart?
For semaglutide, MedVi has the lower introductory price ($179 vs. MyStart's $299 base). Ongoing rates are similar at $299/month. For tirzepatide, MyStart may be cheaper long-term due to the price-lock guarantee — MedVi's tirzepatide pricing can reach $399–$499/month at higher doses.
Does MyStart really lock your price if your dose increases?
Yes — MyStart's price-lock guarantee means your base monthly rate stays the same even when your clinician increases your dose. The lock excludes introductory promotional discounts. Confirm the exact locked rate at checkout.
Does MedVi have any hidden fees?
No. MedVi's monthly price includes the clinician evaluation, medication, shipping, lab work when needed, coaching, and unlimited messaging/telehealth support. No membership fees. The only variable is that tirzepatide pricing may increase with dose escalation.
Can I cancel MedVi anytime?
Yes. MedVi operates month-to-month with no contract. Submit your cancellation at least 72 hours before your billing date via email ([email protected]), portal chat, or phone.
Can I get a refund from MyStart after my medication ships?
No. Per MyStart's published refund policy, once an order has shipped, no refund is available. If you cancel before fulfillment or don't qualify medically, a full refund applies.
Can I use HSA or FSA with either provider?
Both MedVi and MyStart accept HSA/FSA cards. Confirm with your plan administrator that compounded GLP-1 medication qualifies under your specific plan.
Are the medications FDA-approved?
Compounded medications offered by both providers are not FDA-approved as finished products. They are prepared by licensed compounding pharmacies in FDA-regulated facilities. Both providers disclose this clearly. MedVi additionally offers FDA-approved Ozempic and Wegovy at $1,999/month.
Which provider is better for semaglutide?
MedVi. Similar ongoing pricing, but MedVi has the lower entry price, includes free labs, offers oral tablet options, has attributable pharmacy partners, and has 38x more Trustpilot reviews.
Which provider is better for tirzepatide?
It depends on your timeline. For short-term or trial use, MedVi's month-to-month flexibility is advantageous. For 6–12 month commitments at higher doses, MyStart's price-lock can save significant money.
How fast does medication ship?
MedVi: Varies; first orders may take longer than refills. MyStart: FAQ states 2–4 business days after prescription. Both use temperature-controlled shipping.
Does MedVi include lab work?
Yes. Lab work is included when medically necessary, at no additional charge.
Do I need insurance for either program?
No. Both are cash-pay only. No insurance is required or accepted.
What if I don't qualify?
If either provider's clinician determines you're not a candidate for GLP-1 therapy, you won't be charged for medication. MedVi's policy provides a full refund if you're medically disqualified. MyStart provides a refund if you're medically ineligible.
How much weight do people typically lose on GLP-1 medication?
In the STEP 1 trial (semaglutide/Wegovy), participants lost an average of about 14.9% of body weight over 68 weeks. In SURMOUNT-1 (tirzepatide/Zepbound), participants lost 16–22.5% depending on dose over 72 weeks. All participants followed reduced-calorie diets and increased physical activity. Individual results vary. These figures reflect brand-name formulations in controlled clinical settings.
Are compounded GLP-1 medications the same as Wegovy, Ozempic, or Zepbound?
No. Compounded medications are custom-prepared by licensed pharmacies using pharmaceutical-grade ingredients. They are prescribed by licensed providers and dispensed under state and federal pharmacy regulations. However, compounded medications are not FDA-approved as finished products. They haven't undergone the same premarket review for safety, effectiveness, and manufacturing consistency that brand-name drugs go through. Both MedVi and MyStart are transparent about this distinction.
Can I switch between semaglutide and tirzepatide?
Discuss this with your prescribing clinician. Whether switching is appropriate depends on your individual response, tolerance, and clinical situation. Don't assume it's automatically offered — always confirm with your provider.
Which provider is best for beginners?
MedVi. Lower entry price, month-to-month commitment, oral tablet option if you don't want injections, free labs, doctor-led coaching, and the largest Trustpilot review base in the space. It's the most well-rounded option for someone just getting started.
Our Final Recommendation
Here's where we land after reviewing every available page, policy, pricing disclosure, and review for both providers.
These are both solid programs. The right one depends on your priorities.
MedVi is the better fit if you want:
- Lowest semaglutide entry price ($179/month)
- Both injection AND oral tablet options
- Named pharmacy partners (Belmar, per third-party reviews)
- Free labs, free shipping, 24/7 messaging, doctor-led coaching
- Month-to-month flexibility, no contract
- 5-month weight-loss guarantee
- 10,700+ Trustpilot reviews at 4.5/5
MyStart is the better fit if you want:
- Price-lock guarantee — rate stays the same as your dose increases
- 600+ board-certified U.S. physicians
- Named Chief Medical Advisor (Dr. Ritu Chopra)
- Multi-month plan options for lower per-month rates
- LegitScript certified, all-inclusive pricing
- Cost predictability on tirzepatide over 6–12 months
- CEO personally responds to negative reviews
The bottom line:
If you're starting with semaglutide and want the lowest-risk way in, MedVi's month-to-month pricing, money-back guarantee, and massive review base make it the easier first step. If you're planning to use tirzepatide for 6+ months and your top concern is locking in a rate that won't increase, MyStart's price lock is a genuine financial advantage. Neither choice is wrong — both are LegitScript-certified, all-inclusive programs with legitimate clinical oversight.
The most important thing isn't which platform you choose. It's that you choose one, get evaluated by a licensed clinician, and start the process. Every week you spend comparing tabs is a week you could be making progress.
If MedVi fits your priorities:
5-minute assessment. Lowest semaglutide entry price. Oral tablet options. Money-back guarantee. If you don't qualify medically, full refund.
Start Your MedVi Assessment →If MyStart fits your priorities:
Price-lock guarantee on tirzepatide. 600+ board-certified doctors. See if MyStart's locked rate fits your long-term budget.
See MyStart's Current Rates →Still not sure? Take our free 60-second matching quiz →
Sources
- MedVi official website — home.medvi.org — pricing, features, pharmacy disclosure, terms
- MedVi cancellation and refund policy — home.medvi.org/cancellation-and-refund-policy
- MyStart Health official website — mystarthealth.com — pricing, FAQ, price-lock guarantee
- MyStart Health program page — call.mystarthealth.com — plan details, pricing
- Belmar Pharma Solutions — belmarpharmasolutions.com — pharmacy history, licensing, quality standards
- Trustpilot: MedVi — trustpilot.com/review/medvi.org — 10,700+ reviews, 4.5/5 rating (March 2026)
- Trustpilot: MyStart Health — trustpilot.com/review/mystarthealth.com — 280+ reviews (March 2026)
- ConsumerAffairs: MedVi — consumeraffairs.com/health/medvi.html — updated March 13, 2026
- Jastreboff AM, et al. “Semaglutide 2.4 mg — STEP 1 Trial.” New England Journal of Medicine. 2021.
- Jastreboff AM, et al. “Tirzepatide for Obesity — SURMOUNT-1 Trial.” New England Journal of Medicine. 2022.
- FDA: Concerns about unapproved GLP-1 drugs — fda.gov
- LegitScript certification database — legitscript.com
- Wegovy prescribing information — wegovy.com
- Zepbound prescribing information and savings — zepbound.lilly.com
This page is for informational purposes only and does not constitute medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before starting any weight-loss medication. Compounded medications are not FDA-approved as finished products. Individual results vary. Pricing and availability are subject to change — verify directly with each provider before enrolling. Full medical disclaimer
Affiliate disclosure: We earn commissions when you sign up through our links. This revenue funds our research. Our recommendations are based on the data above, not commission rates. Read our full editorial standards
Last updated: March 2026 | Pricing verified: March 2026
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