Obesity Drugs in Development: 87 Trial Records for 14 Programs

By the WPG Research Team · Updated September 2026

This tracker covers 14 selected obesity drugs in development and 87 Phase 3 trial records, checked September 29, 2026. Only CagriSema in this selected set has a documented FDA filing. Weight Loss Provider Guide’s registry review found 38 records marked recruiting. The full table, sources and free CSV are below.

Key obesity drug pipeline statistics (September 2026)

  1. 14 selected drug or combination programs appear in Weight Loss Provider Guide’s September 29, 2026 tracker. Each has Phase 3 records or an FDA filing; this is not a count of the whole pipeline (program table).
  2. 1 of the 14 has a documented FDA filing: Novo Nordisk filed CagriSema on December 18, 2025. Its September 21, 2026 update forecast an FDA decision in Q4 2026; that is a company forecast, not approval (Novo Nordisk).
  3. Q1 2027: Eli Lilly plans to submit retatrutide to the FDA in the first quarter of 2027 (Eli Lilly, July 23, 2026).
  4. 38 of 87 matched Phase 3 trial records listed “recruiting” on September 29, 2026, in Weight Loss Provider Guide’s review of ClinicalTrials.gov (status table; records).
  5. 10 of the 14 programs had at least one matched Phase 3 record listed as recruiting on September 29, 2026, in Weight Loss Provider Guide’s registry review (program table).
  6. 5 of the 14 programs act on amylin receptors: CagriSema, zenagamtide, cagrilintide, eloralintide and petrelintide. None of these five had FDA weight-management approval in the September 29, 2026 sources checked (mechanisms; sources).
  7. 11 of the 14 programs act on at least one target besides GLP-1, and 3 do not act on GLP-1 at all, according to Weight Loss Provider Guide’s classification of the selected programs on September 29, 2026 (mechanisms).
  8. 4 of the 14 programs have an oral Phase 3 record in this registry: aleniglipron, elecoglipron, zenagamtide and ribupatide. Ribupatide’s oral record is a China trial, not its planned global oral program (pill table; checked September 29, 2026).
  9. 2 of the 14 programs test roughly monthly injections: MariTide and berobenatide. Schedules differ by study (Amgen; Pfizer; checked September 29, 2026).
  10. 28.3%: retatrutide’s highest studied dose produced 28.3% average weight loss at 80 weeks in TRIUMPH-1 under the efficacy analysis, or 25.0% under the treatment-regimen analysis. This is a selected trial result, not a cross-trial record (Lilly, May 21, 2026).
  11. 37 of 69 ongoing or planned records with estimated primary completion dates list 2028, in Weight Loss Provider Guide’s September 29, 2026 registry review. These are dates for collecting primary-outcome data, not result releases or approvals (date table).
  12. 13 to 200+: the seven selected publisher counts in Weight Loss Provider Guide’s September 2026 comparison range from 13 to more than 200. Their scopes differ; paid underlying lists were not independently recounted (count audit).
  13. September 22, 2026: Zealand Pharma announced petrelintide’s Phase 3 program initiation. The three matched records still listed “not yet recruiting” in their September 28 updates (Zealand; records).
  14. 100 days apart: the FDA approved the Wegovy pill on December 22, 2025, and Foundayo on April 1, 2026—the first two oral GLP-1 medicines for weight loss (Novo Nordisk; FDA).

On this page: The 14 drugs · How many are in development · When they could be approved · Reported weight loss · What's different · Pills and monthly shots · Recruiting trials · Names and counts · What changed · Can I get them now? · Method · Cite · Download · FAQ · Sources

Which obesity drugs are in late-stage development?

The 14 selected programs have 87 matched Phase 3 records. One has a documented FDA filing. Four others have reported Phase 3 obesity results, eight have Phase 3 trials running, and one has an announced start with records still marked “not yet recruiting.”

A “program” here means one drug or fixed combination; it can have several trials. The FDA is the U.S. Food and Drug Administration. Phase 3 tests a drug in larger groups before an approval decision. Think of it like a final exam, but a program can have several exams running at once. CagriSema has submitted an FDA application. A reported result does not mean every trial for that drug has ended (FDA).

Table 1. The 14 selected late-stage obesity programs, September 29, 2026
Drug or program (other names)MakerActs onFormStage, Sept. 29, 2026Phase 3 records (recruiting)Example trial records
CagriSema (cagrilintide + semaglutide)Novo NordiskGLP-1 + amylin (two medicines in one shot)Injection, weeklyFDA filing/review11 (2)NCT05567796, NCT06131437
Retatrutide (LY3437943)Eli LillyGIP + GLP-1 + glucagon (triple)Injection, weeklyPhase 3 - obesity results reported10 (0)NCT05929066, NCT05882045
Survodutide (BI 456906)Boehringer IngelheimGLP-1 + glucagonInjection, weeklyPhase 3 - obesity results reported6 (0)NCT06066515, NCT06077864
MariTide (maridebart cafraglutide; AMG 133)AmgenTurns on GLP-1, blocks the GIP receptorInjection, monthly or less oftenPhase 3 - underway10 (5)NCT06858839, NCT07037433
Eloralintide (LY3841136)Eli LillyAmylin onlyInjection, weeklyPhase 3 - underway5 (5)NCT07321886, NCT07282600
Zenagamtide (amycretin; NNC0487-0111; NN9487)Novo NordiskGLP-1 + amylin in one moleculeInjection and pill, weekly shot; daily pillPhase 3 - underway13 (10)NCT07339423, NCT07720271
Cagrilintide (cagrilintide 2.4 mg alone)Novo NordiskAmylin receptors; also calcitonin receptor activityInjection, weeklyPhase 3 - obesity results reported5 (2)NCT07220642, NCT07220759
VK2735 (injection)Viking TherapeuticsGLP-1 + GIPInjection, weeklyPhase 3 - underway2 (0)NCT07104500, NCT07104383
Aleniglipron (GSBR-1290)Structure TherapeuticsGLP-1 only (small-molecule pill)Pill, dailyPhase 3 - underway2 (2)NCT07654361, NCT07654374
Elecoglipron (AZD5004; ECC5004)AstraZenecaGLP-1 only (small-molecule pill)Pill, dailyPhase 3 - underway2 (2)NCT07667803, NCT07775404
Berobenatide (PF-08653944; PF'3944; MET-097i; MET097; MET-097)PfizerGLP-1 only (long-acting)Injection, weekly and monthly regimens; schedule differs by trialPhase 3 - underway8 (2)NCT07595549, NCT07400653
Enicepatide (CT-388; RO7795068; RG6640)RocheGLP-1 + GIPInjection, weeklyPhase 3 - underway3 (3)NCT07351045, NCT07351058
Ribupatide (KAI-9531; HRS9531)Kailera Therapeutics; Hengrui/Fujian Shengdi in ChinaGLP-1 + GIPInjection and pill, weekly injection; oral tablet tested separately in chinaPhase 3 - obesity results reported9 (6)NCT07284875, NCT07284901
Petrelintide (ZP8396; RO7895515)Zealand Pharma with RocheAmylin onlyInjection, weeklyPhase 3 start announced; not yet recruiting3 (0)NCT07843498, NCT07843485

Source: Weight Loss Provider Guide Research, obesity drug pipeline tracker, checked September 29, 2026. Stages come from company announcements; trial records from ClinicalTrials.gov. "Records (recruiting)" counts the Phase 3 obesity trial records we matched to each drug and how many listed "recruiting."

Among 14 selected obesity programs, 1 has an FDA filing, 4 others have Phase 3 obesity results, 8 have Phase 3 trials running, and 1 has an announced initiation with records not yet recruiting.

1 documented FDA filing among 14 selected obesity programs

Source: Weight Loss Provider Guide Research; company announcements and ClinicalTrials.gov. Selected 14-program reference, checked Sept. 29, 2026.

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Our counting rule

This is a selected reference, not an exhaustive screen of every obesity program. We checked the 14 named programs against these rules:

  1. The FDA has not approved it for chronic weight management.
  2. Its maker announced Phase 3 initiation in adults with obesity or overweight, a Phase 3 record is registered, or the maker has filed it with the FDA. A registered study that has not opened is labeled separately.
  3. It's one drug or one fixed combination. A pill and a shot of the same drug share one row.

The watchlist gives separate examples of planned formulations, region-specific approvals and rare-obesity programs. Approval outside the U.S. does not by itself determine inclusion. We include China trials for ribupatide, so this is not a U.S.-only trial list.

How many obesity drugs are in development?

It depends on what you count. The published counts below run from 13 to more than 200. Some cover broad pipelines; others list a handful to watch. Our 14 is the size of a selected reference, not a worldwide total or a count of drugs certain to reach pharmacies.

Table 2. Published counts of obesity drugs in development, 2026
SourceDate or page editionCount statedWhat it counts
Weight Loss Provider Guide Research2026-09-291414 selected drug or combination programs with Phase 3 records or FDA filing/review; one row per program; not a worldwide census
Becker's Hospital Review2026-09-0213The 'most closely watched' experimental drugs; includes Phase 2, China-approved and a stopped program
GoodRx2026-07-23 (page date); title checked 2026-09-2914'New weight loss drugs'; list size shown in the page title
Expert Market Research2026 (report page)100+Pipeline candidates advertised in a paid report; over 100 stated on public sales page
IQVIA2026-02-19120+Drugs in active development
Ozmosi2026-08-17 (page date); checked 2026-09-29150+Active programs from lab stage through Phase 3, obesity and related conditions
ResearchAndMarkets (GlobeNewswire release)2026-09-23200+Marketed and experimental obesity drugs together (paid report)

Source: each publisher, linked; compiled by Weight Loss Provider Guide Research, checked September 29, 2026.

These figures are not a like-for-like comparison. We verified what each public page says, not the contents of paid reports. A “200+” claim is a lower bound, not an exact count, and none of these counts tells us how many drugs will reach a pharmacy in the next few years.

Seven selected publisher counts range from 13 to more than 200. They cover different selections, development stages and approval statuses, so they cannot be compared as equivalent totals.

Published pipeline counts: 13 to 200+, with different scopes

Sources: WPG Research, Becker's, GoodRx, Expert Market Research, IQVIA, Ozmosi and ResearchAndMarkets. Public wording checked Sept. 29, 2026; paid underlying datasets not audited.

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Why two short lists don't match

Becker's list and ours are almost the same size, 13 and 14. They share only 9 drugs.

Becker's includes four drugs outside our selected list: APHD-012 (Phase 2 work reported by Aphaia), ARD-101 (its HERO trial ended), and ecnoglutide and mazdutide (China approvals). Ours includes five it leaves out: cagrilintide, elecoglipron, enicepatide, ribupatide and petrelintide.

Same size, different drugs. That's why a count needs its rule printed next to it.

When will the new obesity drugs be approved?

The sources checked do not establish a confirmed FDA approval date for any of the 14. Novo forecast a Q4 2026 decision on CagriSema; Lilly plans a retatrutide filing in Q1 2027. These are company plans, not approved launch dates (Novo; Lilly).

Table 3. Next public milestones for the 14 drugs, September 29, 2026
DrugStageVerified milestone—not necessarily the latestNext milestone or date in the checked sources
CagriSemaFDA filing/reviewNovo reported new Phase 3 results and a Q4 2026 FDA decision forecast (2026-09-21)FDA decision expected Q4 2026 (Novo forecast; not approval)
RetatrutidePhase 3 - obesity results reportedTRIUMPH-2 and TRIUMPH-3 topline results (2026-07-23)FDA filing planned Q1 2027 (Lilly)
SurvodutidePhase 3 - obesity results reportedSYNCHRONIZE-1 topline results (2026-04-28)No filing date established by the sources checked; SYNCHRONIZE-CVOT lists completed (registry update September 17, 2026)
MariTidePhase 3 - underwayMARITIME-1-EXTENSION lists recruiting (2026-09-03)MARITIME-1 estimated primary completion Jan 2027 (registry)
EloralintidePhase 3 - underwayENLIGHTEN-1 record lists recruiting (2026-09-22)ENLIGHTEN-1 estimated primary completion Mar 2028 (registry)
ZenagamtidePhase 3 - underwayAMAZE 9 oral record lists recruiting (2026-09-28)AMAZE 9 estimated primary completion June 27, 2028 (registry)
CagrilintidePhase 3 - obesity results reportedRENEW 1 and RENEW 2 started (2025-11-05)RENEW 1 estimated primary completion May 2027 (registry)
VK2735 (injection)Phase 3 - underwayVANQUISH trials fully enrolled (2026-07-29)Pill version: Phase 3 start expected Q4 2026 (company)
AleniglipronPhase 3 - underwayACCOMPLISH-1 registry lists actual study start (2026-07-13)ACCOMPLISH-1 estimated primary completion September 2028 (registry)
ElecoglipronPhase 3 - underwayEMBOLD started (2026-06-29)EMBOLD estimated primary completion Jul 31, 2028 (AstraZeneca)
BerobenatidePhase 3 - underwayNew monthly-switch study registered; not yet recruiting (2026-09-29)VESPER-6 estimated primary completion May 4, 2028 (registry)
EnicepatidePhase 3 - underwayChina Phase 3 started (2026-07-03)Enith1 estimated primary completion Jul 2028 (registry)
RibupatidePhase 3 - obesity results reportedChina oral HRS9531 Phase 3 started (registry); global KaiNETIC program ongoing (2026-07-24)Global KaiNETIC results expected 2028; global oral Phase 3 planned as early as 1H 2027 (Kailera)
PetrelintidePhase 3 start announced; not yet recruitingZUPREME Phase 3 program announced (2026-09-22)ZUPREME-3 estimated primary completion Dec 2028 (registry)

Source: company announcements and ClinicalTrials.gov, linked in Table 1 and the dataset; checked September 29, 2026. "Estimated" dates come from the trial record and can move.

What the trial dates mean

A trial's "primary completion date" is when it finishes collecting data for its main question. It is not a launch date or a promise of when results will be published. Results, an FDA application and an approval decision are separate steps; follow-up studies can continue during review (ClinicalTrials.gov; FDA).

Of the 70 ongoing or planned Phase 3 records we matched, 69 list an estimated primary completion date. Thirty-seven of them, a little over half, point to 2028.

Table 4. Estimated primary completion year, ongoing or planned Phase 3 records
Estimated primary completion yearTrial records
20263
202720
202837
20297
20302
Total with an estimated date69

Source: ClinicalTrials.gov records compiled by Weight Loss Provider Guide Research, checked September 29, 2026. Of the 70 ongoing or planned records, 1 lists an actual primary completion date that has already passed. None has a blank primary completion date in this snapshot.

Of 69 ongoing or planned matched Phase 3 records with estimated primary completion dates, 3 list 2026, 20 list 2027, 37 list 2028, 7 list 2029 and 2 list 2030.

37 of 69 estimated primary completion dates fall in 2028

Source: ClinicalTrials.gov records compiled by Weight Loss Provider Guide Research. 69 estimated dates within 70 ongoing/planned matched records; checked Sept. 29, 2026.

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What "Phase 3," "filed" and "approved" mean

  • Phase 3: large trials, often with thousands of people, that test whether a drug works and is safe enough to approve.
  • Filed: the company has sent the FDA its full application. Filing is not approval.
  • Approved: the FDA has said yes for a specific use. Approval of a drug, trial access and a clinician’s prescribing decisions are different things.

Why a trial can stay "active" after its main results

Some trials keep going after the main question is answered. CagriSema's REDEFINE 1 record lists an actual primary completion date in October 2024 but was still "active, not recruiting" on September 29, 2026, because it includes an extension (ClinicalTrials.gov NCT05567796).

How much weight do the new drugs help people lose?

Retatrutide produced 28.3% average weight loss at 80 weeks in TRIUMPH-1 under the efficacy analysis, or 25.0% under the treatment-regimen analysis, Lilly reported. This is one selected result, not the highest result across every study or extension. The trials below differ in length, dose and who took part, so these numbers are not a ranking.

Here's what 28.3% looks like. People in TRIUMPH-1 started at about 248 pounds on average. On the top dose, they lost about 70 pounds (Eli Lilly).

Table 5. Selected reported weight-loss results—not a ranking
DrugTrial (phase)WeeksReported weight-loss measureHow it was countedPlacebo groupSource
RetatrutideTRIUMPH-1 (Phase 3)8028.3%If everyone stayed on the drug; 25.0% counting everyone2.2% / 3.9%Eli Lilly
CagriSemaREDEFINE 1 (Phase 3)6822.7%If everyone stayed on the drug; 20.4% counting everyone2.3% / 3.0%Novo Nordisk
SurvodutideSYNCHRONIZE-1 (Phase 3)7616.6%If everyone stayed on the drug3.2%Boehringer Ingelheim
CagrilintideREDEFINE 1, cagrilintide-alone arm (Phase 3)6811.8%If everyone stayed on the drug; 11.5% counting everyone2.3% / 3.0%Novo Nordisk
AleniglipronACCESS II (Phase 2)4415.3% (reported placebo-adjusted difference: 16.3 percentage points)If everyone stayed on the drugGained 1.1%Structure Therapeutics
BerobenatideVESPER-3 (Phase 2b), monthly dose2812.3 percentage points more weight loss than placeboIf everyone stayed on the drugAlready subtractedPfizer
ElecoglipronVISTA (Phase 2b)3611.8%Efficacy analysis, 75 mg cohort0.3%AstraZeneca
EloralintidePhase 24820.1%If everyone stayed on the drug, top dose0.4%Eli Lilly
EnicepatideCT388-103 (Phase 2)4822.5 percentage points more weight loss than placeboIf everyone stayed on the drug; 18.3 percentage points under the treatment-regimen analysisAlready subtractedRoche
MariTidePhase 2, adults without type 2 diabetes52Up to 19.9%Efficacy analysis; up to 16.2% under treatment-policy analysis2.6% / 2.5%Amgen
PetrelintideZUPREME-1 (Phase 2)42Up to 10.7%Efficacy analysis; 10.2% under treatment-policy analysis1.7% / 1.4%Zealand Pharma
VK2735 (injection)VENTURE (Phase 2)13Up to 14.7%As reported; a short trialNot shownViking Therapeutics
ZenagamtidePhase 2, people with type 2 diabetes36Up to 14.5%As reportedNot shownNovo Nordisk
RibupatideGEMINI-1 (Phase 3), China, adults without diabetes48Up to 19.2%Hypothetical analysis; 17.7% under treatment-policy analysis1.4% / 1.4%Kailera

Source: each company's release, linked. Compiled by Weight Loss Provider Guide Research, checked September 29, 2026. Results come from different trials, lengths, doses and groups of people. “Placebo-adjusted” means the difference between treatment and placebo, in percentage points—not a relative percent improvement. Most rows are absolute body-weight loss; the berobenatide and enicepatide rows are adjusted differences. “Not shown” means not transcribed from the linked release, not absent from all trial reports.

Petrelintide’s result release was posted September 29, 2026 U.S. time and is datelined September 30 in Denmark; the source date is not silently changed.

Rounding in the source: Structure reports 15.3% loss versus 1.1% gain and a placebo-adjusted difference of 16.3 percentage points. Subtracting the displayed rounded values gives 16.4. We keep the reported 16.3 and show the mismatch rather than silently change the source (Structure).

Different time, different group: Lilly also reported 30.3% at 104 weeks in a selected TRIUMPH-1 extension. It included people with a starting BMI of at least 35 who completed the main study and tolerated treatment. That is not the full 80-week study population (Lilly).

You can read more about retatrutide's trial results and side effects, or see how retatrutide compares with tirzepatide, which is already approved.

Why the same trial has two weight-loss numbers

Many trials report two answers. An estimand is the treatment-effect question an analysis is designed to answer. The details vary by trial.

  • "If everyone had stayed on the drug" (the efficacy estimand). This estimates the result under continued treatment and the study’s other rules; it is not simply an average of people who finished.
  • "Counting everyone assigned the drug" (the treatment-regimen or treatment-policy estimand). This estimates the effect regardless of treatment adherence, using the study’s rules for missing data and other treatments.

Take retatrutide's TRIUMPH-4 trial. On the 12 mg dose at 68 weeks, Lilly reported 28.7% weight loss the first way and 23.7% the second way (Eli Lilly). That's a gap of 5.0 percentage points. Same drug, same trial, same people. Just two different questions.

When quoting a result, name the trial, group, duration and analysis. Show both estimates when the difference matters. Neither should be renamed a “real-world” result.

What's different about the new obesity drugs?

Eleven of the 14 act on something besides GLP-1 (glucagon-like peptide-1), the gut hormone whose action Wegovy mimics. Five act on amylin receptors, which help signal fullness. Three skip GLP-1 entirely (mechanism sources).

Table 6. What the 14 drugs act on
What it acts onDrugsCount
GLP-1 onlyAleniglipron, elecoglipron, berobenatide3
GLP-1 + GIPVK2735, enicepatide, ribupatide3
Amylin-based, no GLP-1Eloralintide, cagrilintide, petrelintide3
GLP-1 + amylinCagriSema, zenagamtide2
GLP-1 + glucagonSurvodutide1
GIP + GLP-1 + glucagonRetatrutide1
GLP-1 on, GIP receptor blockedMariTide1
Total14

Source: Weight Loss Provider Guide Research classification of Lilly, Novo, Amgen, Viking, Structure, AstraZeneca, Pfizer, Roche, Kailera, Zealand and cagrilintide receptor research; checked September 29, 2026. Cagrilintide also acts at calcitonin receptors; “amylin-based” does not mean an exclusive receptor target.

Three selected programs act only on GLP-1; 11 add or use other targets, including 5 amylin-based programs.

11 of 14 selected obesity programs act beyond GLP-1 alone

Source: Weight Loss Provider Guide Research classification of company descriptions and receptor research. Selected 14-program reference; checked Sept. 29, 2026.

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Amylin: the fullness hormone behind 5 of the 14

Your pancreas releases amylin with insulin after you eat. It helps tell your brain you’re full (Lilly; receptor research). Five of the selected programs act on amylin receptors. Two mix that action with GLP-1 (CagriSema and zenagamtide). Three are amylin-based without GLP-1 (eloralintide, cagrilintide and petrelintide). Cagrilintide also has calcitonin-receptor activity.

None of these five programs had FDA weight-management approval in the sources checked. Novo describes CagriSema as a proposed first combination of a GLP-1 medicine and an amylin analogue for weight management (Novo Nordisk).

GIP and glucagon

GIP (glucose-dependent insulinotropic polypeptide) is another gut hormone. Zepbound, which is already approved, works on both GIP and GLP-1. Three drugs on this list do the same: VK2735, enicepatide and ribupatide.

Glucagon is a hormone that helps the body burn stored energy. Survodutide pairs it with GLP-1. Retatrutide works on all three: GIP, GLP-1 and glucagon.

The one that blocks instead of boosts

MariTide is the odd one out. It turns GLP-1 on but blocks the GIP receptor. It's also built to be given about once a month instead of once a week (Amgen).

Are new weight-loss pills and monthly shots coming?

Four of the selected programs have an oral Phase 3 example: aleniglipron, elecoglipron, zenagamtide and ribupatide. Two also test roughly monthly shots: MariTide and berobenatide. The sources checked do not establish an FDA filing for any of these six programs.

Table 7. Pills and monthly shots in late-stage testing, September 29, 2026
DrugFormStageExample Phase 3 record
AleniglipronDaily pillPhase 3 underwayNCT07654361
ElecoglipronDaily pillPhase 3 underwayNCT07667803
ZenagamtideDaily pill (also a weekly shot)Phase 3 underwayNCT07720271 (tablets)
RibupatideOral HRS9531 tablet in China (also an injection program)Phase 3, recruiting in the China recordNCT07670884 (tablets)
MariTideShot, about monthly or less oftenPhase 3 underwayNCT06858839
BerobenatideShot, weekly then monthlyPhase 3 underwayNCT07595549 (monthly)

Source: company announcements and ClinicalTrials.gov records, checked September 29, 2026.

Two oral GLP-1 medicines are already FDA-approved for weight loss: the Wegovy pill, approved December 22, 2025, and Foundayo, approved April 1, 2026. Those approvals were 100 days apart. Other kinds of weight-loss pills existed before them (Novo Nordisk; FDA).

A pill and a shot of the same drug can be at different stages. Viking's VK2735 shot is in Phase 3, but Viking expects to start Phase 3 for its pill in the fourth quarter of 2026 (Viking Therapeutics). So "VK2735 is in Phase 3" is true only for the shot.

Ribupatide’s China tablet record is already Phase 3. Kailera’s separate plan for global oral Phase 3 trials as early as the first half of 2027 does not erase that China record (registry; Kailera).

For pills you can get now, see our look at oral GLP-1 options and where oral tirzepatide stands.

Which Phase 3 obesity trials are recruiting?

Of the 87 Phase 3 records matched to the 14 selected programs, 38 listed “recruiting” on ClinicalTrials.gov on September 29, 2026. Another 22 were active but not recruiting, 10 had not opened, 16 were completed and 1 was withdrawn. Ten of the 14 programs had at least one recruiting record.

Table 8. Phase 3 trial records by status, September 29, 2026
Status on ClinicalTrials.govRecordsWhat it means
Recruiting38The study says it is enrolling people
Active, not recruiting22Running, but not currently enrolling
Not yet recruiting10Registered, not yet enrolling
Completed16Finished
Withdrawn1Stopped before anyone enrolled
Total87

Source: ClinicalTrials.gov records compiled by Weight Loss Provider Guide Research, checked September 29, 2026.

Of 87 matched Phase 3 records, 38 were recruiting, 22 active but not recruiting, 10 not yet recruiting, 16 completed and 1 withdrawn.

38 of 87 matched Phase 3 records listed recruiting

Source: ClinicalTrials.gov records compiled by Weight Loss Provider Guide Research. Disclosed selected-program query, checked Sept. 29, 2026.

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Four selected programs had no recruiting record in this query on the check date: retatrutide, survodutide, the VK2735 shot and petrelintide. Petrelintide’s matched records were registered but had not opened. This does not establish that no other recruiting trial exists outside the query.

"Recruiting" is a starting point, not a promise. It doesn't mean a site near you has room, or that you qualify. The study record lists the sites and the rules.

Look up a drug or trial

Type a drug name, an old code name or a trial number (it starts with "NCT"). You can also filter by status, drug or year. The full table below works without the search box.

Search the Phase 3 trial records

Filter the 87 matched records by drug, trial name, NCT number, status or estimated primary-completion year. Filtering stays in this browser; search terms are not sent or stored.

Programs
Program characteristics
Estimated primary completion

Includes estimated dates only, not dates marked actual.

87 records across 14 programs

  1. Primary completion
    2028-09 (estimated)
    Enrollment
    3600 (estimated)
    Last registry update
    2026-08-10
    Source and record notes
    Formulation checked
    Pill
    Record checked
    2026-09-29
  2. Primary completion
    2028-09 (estimated)
    Enrollment
    1100 (estimated)
    Last registry update
    2026-09-11
    Source and record notes
    Formulation checked
    not checked for this record
    Record checked
    2026-09-29
  3. Active Not Recruiting
    Primary completion
    2027-09-21 (estimated)
    Enrollment
    3578 (actual)
    Last registry update
    2026-09-24
    Source and record notes
    Formulation checked
    not checked for this record
    Record checked
    2026-09-29
    Note
    Added after searching earlier drug names/codes in the registry; core fields checked directly in the live v2 response.
  4. Berobenatide

    PF-08653944 in obesity/overweight and type 2 diabetes

    NCT07400653 on ClinicalTrials.gov (opens in a new tab)
    Active Not Recruiting
    Primary completion
    2027-10-12 (estimated)
    Enrollment
    1078 (actual)
    Last registry update
    2026-09-25
    Source and record notes
    Formulation checked
    not checked for this record
    Record checked
    2026-09-29
    Note
    Added after searching earlier drug names/codes in the registry; core fields checked directly in the live v2 response.
  5. Berobenatide

    VESPER-6 (monthly dosing)

    NCT07595549 on ClinicalTrials.gov (opens in a new tab)
    Recruiting
    Primary completion
    2028-05-04 (estimated)
    Enrollment
    954 (estimated)
    Last registry update
    2026-09-28
    Source and record notes
    Formulation checked
    Injection
    Record checked
    2026-09-29
    Note
    Registry fields rechecked directly on 2026-09-29; earlier missing or rounded fields corrected.
  6. Berobenatide

    Weekly berobenatide, China

    NCT07792954 on ClinicalTrials.gov (opens in a new tab)
    Not Yet Recruiting
    Primary completion
    2028-03-14 (estimated)
    Enrollment
    300 (estimated)
    Last registry update
    2026-09-25
    Source and record notes
    Formulation checked
    not checked for this record
    Record checked
    2026-09-29
    Note
    Added after searching earlier drug names/codes in the registry; core fields checked directly in the live v2 response.
  7. Not Yet Recruiting
    Primary completion
    2029-03-14 (estimated)
    Enrollment
    180 (estimated)
    Last registry update
    2026-09-25
    Source and record notes
    Formulation checked
    not checked for this record
    Record checked
    2026-09-29
    Note
    Added after searching earlier drug names/codes in the registry; core fields checked directly in the live v2 response.
  8. Not Yet Recruiting
    Primary completion
    2029-02-21 (estimated)
    Enrollment
    197 (estimated)
    Last registry update
    2026-09-25
    Source and record notes
    Formulation checked
    not checked for this record
    Record checked
    2026-09-29
    Note
    Added after searching earlier drug names/codes in the registry; core fields checked directly in the live v2 response.
  9. Primary completion
    2028-04-30 (estimated)
    Enrollment
    258 (estimated)
    Last registry update
    2026-09-29
    Source and record notes
    Formulation checked
    not checked for this record
    Record checked
    2026-09-29
    Note
    Added after searching earlier drug names/codes in the registry; core fields checked directly in the live v2 response.
  10. Berobenatide

    Switching to monthly berobenatide for weight maintenance

    NCT07845500 on ClinicalTrials.gov (opens in a new tab)
    Not Yet Recruiting
    Primary completion
    2028-02-16 (estimated)
    Enrollment
    660 (estimated)
    Last registry update
    2026-09-29
    Source and record notes
    Formulation checked
    not checked for this record
    Record checked
    2026-09-29
    Note
    Added after searching earlier drug names/codes in the registry; core fields checked directly in the live v2 response.
  11. Primary completion
    2025-01-28 (actual)
    Enrollment
    1200 (actual)
    Last registry update
    2026-01-28
    Source and record notes
    Formulation checked
    not checked for this record
    Record checked
    2026-09-29
  12. Completed
    Primary completion
    2025-01-17 (actual)
    Enrollment
    331 (actual)
    Last registry update
    2026-01-22
    Source and record notes
    Formulation checked
    not checked for this record
    Record checked
    2026-09-29
  13. Primary completion
    2025-01-06 (actual)
    Enrollment
    300 (actual)
    Last registry update
    2026-01-09
    Source and record notes
    Formulation checked
    not checked for this record
    Record checked
    2026-09-29
  14. CagriSema

    CagriSema versus tirzepatide

    NCT06131437 on ClinicalTrials.gov (opens in a new tab)
    Completed
    Primary completion
    2025-12-08 (actual)
    Enrollment
    809 (actual)
    Last registry update
    2026-02-06
    Source and record notes
    Formulation checked
    not checked for this record
    Record checked
    2026-09-29
  15. Completed
    Primary completion
    2026-04-22 (actual)
    Enrollment
    300 (actual)
    Last registry update
    2026-05-05
    Source and record notes
    Formulation checked
    not checked for this record
    Record checked
    2026-09-29
  16. CagriSema

    CagriSema long-term weight-loss study

    NCT06780449 on ClinicalTrials.gov (opens in a new tab)
    Active Not Recruiting
    Primary completion
    2028-08-28 (estimated)
    Enrollment
    400 (estimated)
    Last registry update
    2026-01-20
    Source and record notes
    Formulation checked
    not checked for this record
    Record checked
    2026-09-29
  17. CagriSema

    CagriSema long-term maintenance study

    NCT07011667 on ClinicalTrials.gov (opens in a new tab)
    Active Not Recruiting
    Primary completion
    2027-03-01 (estimated)
    Enrollment
    609 (actual)
    Last registry update
    2026-07-24
    Source and record notes
    Formulation checked
    not checked for this record
    Record checked
    2026-09-29
  18. CagriSema

    CagriSema formulation comparison

    NCT07357766 on ClinicalTrials.gov (opens in a new tab)
    Withdrawn
    Primary completion
    2027-11-29 (estimated)
    Enrollment
    0 (actual)
    Last registry update
    2026-07-09
    Source and record notes
    Formulation checked
    not checked for this record
    Record checked
    2026-09-29
    Note
    Withdrawn with zero enrolled. Does not mean the CagriSema program stopped.
  19. CagriSema

    CagriSema doses versus semaglutide

    NCT07564414 on ClinicalTrials.gov (opens in a new tab)
    Recruiting
    Primary completion
    2028-02-23 (estimated)
    Enrollment
    2500 (estimated)
    Last registry update
    2026-08-31
    Source and record notes
    Formulation checked
    not checked for this record
    Record checked
    2026-09-29
  20. Active Not Recruiting
    Primary completion
    2024-10-30 (actual)
    Enrollment
    3400 (estimated)
    Last registry update
    2026-08-31
    Source and record notes
    Formulation checked
    Injection
    Record checked
    2026-09-29
    Note
    Includes separate CagriSema and cagrilintide-alone randomized arms; counted once as a record and in both program memberships. Primary completion is actual; follow-up continues. Registry enrollment: 3400 estimated; Novo REDEFINE 1 announcement: 3417 randomized. These separately reported figures were not reconciled.
  21. CagriSema · Cagrilintide

    Cagrilintide/CagriSema pediatric study

    NCT07253285 on ClinicalTrials.gov (opens in a new tab)
    Recruiting
    Primary completion
    2030-03-20 (estimated)
    Enrollment
    460 (estimated)
    Last registry update
    2026-08-31
    Source and record notes
    Formulation checked
    not checked for this record
    Record checked
    2026-09-29
    Note
    Children and teens; counted once in totals but listed under both CagriSema and cagrilintide.
  22. Active Not Recruiting
    Primary completion
    2027-05-11 (estimated)
    Enrollment
    300 (estimated)
    Last registry update
    2026-08-06
    Source and record notes
    Formulation checked
    Injection
    Record checked
    2026-09-29
  23. Active Not Recruiting
    Primary completion
    2027-05-12 (estimated)
    Enrollment
    330 (estimated)
    Last registry update
    2026-09-04
    Source and record notes
    Formulation checked
    not checked for this record
    Record checked
    2026-09-29
  24. Primary completion
    2027-05-18 (estimated)
    Enrollment
    285 (estimated)
    Last registry update
    2026-09-04
    Source and record notes
    Formulation checked
    not checked for this record
    Record checked
    2026-09-29
  25. Recruiting
    Primary completion
    2028-07-31 (estimated)
    Enrollment
    4500 (estimated)
    Last registry update
    2026-09-09
    Source and record notes
    Formulation checked
    Pill
    Record checked
    2026-09-29
    Note
    One registry record covers two independent pivotal studies, with and without type 2 diabetes; counted once as an NCT record.
  26. Elecoglipron

    Elecoglipron Asian participants

    NCT07775404 on ClinicalTrials.gov (opens in a new tab)
    Recruiting
    Primary completion
    2027-06-04 (estimated)
    Enrollment
    351 (estimated)
    Last registry update
    2026-08-27
    Source and record notes
    Formulation checked
    not checked for this record
    Record checked
    2026-09-29
  27. Primary completion
    2028-01 (estimated)
    Enrollment
    1035 (estimated)
    Last registry update
    2026-09-22
    Source and record notes
    Formulation checked
    not checked for this record
    Record checked
    2026-09-29
  28. Primary completion
    2028-03 (estimated)
    Enrollment
    1980 (estimated)
    Last registry update
    2026-09-22
    Source and record notes
    Formulation checked
    Injection
    Record checked
    2026-09-29
  29. Primary completion
    2028-03 (estimated)
    Enrollment
    900 (estimated)
    Last registry update
    2026-09-22
    Source and record notes
    Formulation checked
    not checked for this record
    Record checked
    2026-09-29
  30. Primary completion
    2028-03 (estimated)
    Enrollment
    800 (estimated)
    Last registry update
    2026-09-22
    Source and record notes
    Formulation checked
    not checked for this record
    Record checked
    2026-09-29
  31. Primary completion
    2028-06 (estimated)
    Enrollment
    900 (estimated)
    Last registry update
    2026-09-22
    Source and record notes
    Formulation checked
    not checked for this record
    Record checked
    2026-09-29
  32. Primary completion
    2028-07-24 (estimated)
    Enrollment
    2000 (estimated)
    Last registry update
    2026-09-14
    Source and record notes
    Formulation checked
    Injection
    Record checked
    2026-09-29
  33. Primary completion
    2028-08-07 (estimated)
    Enrollment
    1600 (estimated)
    Last registry update
    2026-09-14
    Source and record notes
    Formulation checked
    not checked for this record
    Record checked
    2026-09-29
  34. Enicepatide

    Enicepatide mixed-diabetes-status study

    NCT07670416 on ClinicalTrials.gov (opens in a new tab)
    Recruiting
    Primary completion
    2028-02-24 (estimated)
    Enrollment
    300 (estimated)
    Last registry update
    2026-09-10
    Source and record notes
    Formulation checked
    not checked for this record
    Record checked
    2026-09-29
  35. Active Not Recruiting
    Primary completion
    2027-01-21 (estimated)
    Enrollment
    3853 (actual)
    Last registry update
    2026-09-17
    Source and record notes
    Formulation checked
    Injection
    Record checked
    2026-09-29
  36. Active Not Recruiting
    Primary completion
    2027-01-21 (estimated)
    Enrollment
    1105 (actual)
    Last registry update
    2025-12-31
    Source and record notes
    Formulation checked
    not checked for this record
    Record checked
    2026-09-29
  37. Active Not Recruiting
    Primary completion
    2027-04-27 (estimated)
    Enrollment
    279 (actual)
    Last registry update
    2025-12-17
    Source and record notes
    Formulation checked
    not checked for this record
    Record checked
    2026-09-29
  38. Primary completion
    2028-06-30 (estimated)
    Enrollment
    12800 (estimated)
    Last registry update
    2026-09-22
    Source and record notes
    Formulation checked
    not checked for this record
    Record checked
    2026-09-29
  39. Primary completion
    2028-06-30 (estimated)
    Enrollment
    5056 (estimated)
    Last registry update
    2026-09-16
    Source and record notes
    Formulation checked
    not checked for this record
    Record checked
    2026-09-29
  40. Active Not Recruiting
    Primary completion
    2027-09-03 (estimated)
    Enrollment
    250 (estimated)
    Last registry update
    2026-09-18
    Source and record notes
    Formulation checked
    not checked for this record
    Record checked
    2026-09-29
  41. Active Not Recruiting
    Primary completion
    2027-08-30 (estimated)
    Enrollment
    250 (estimated)
    Last registry update
    2026-09-29
    Source and record notes
    Formulation checked
    not checked for this record
    Record checked
    2026-09-29
  42. Primary completion
    2028-01-03 (estimated)
    Enrollment
    300 (estimated)
    Last registry update
    2026-08-27
    Source and record notes
    Formulation checked
    not checked for this record
    Record checked
    2026-09-29
  43. Recruiting
    Primary completion
    2027-12-26 (estimated)
    Enrollment
    950 (estimated)
    Last registry update
    2026-09-03
    Source and record notes
    Formulation checked
    not checked for this record
    Record checked
    2026-09-29
  44. Recruiting
    Primary completion
    2027-12-26 (estimated)
    Enrollment
    3200 (estimated)
    Last registry update
    2026-09-03
    Source and record notes
    Formulation checked
    not checked for this record
    Record checked
    2026-09-29
  45. Not Yet Recruiting
    Primary completion
    2030-07-28 (estimated)
    Enrollment
    2500 (estimated)
    Last registry update
    2026-09-28
    Source and record notes
    Formulation checked
    not checked for this record
    Record checked
    2026-09-29
    Note
    Zealand announced the ZUPREME Phase 3 start on Sep 22, 2026.
  46. Not Yet Recruiting
    Primary completion
    2028-10-20 (estimated)
    Enrollment
    600 (estimated)
    Last registry update
    2026-09-28
    Source and record notes
    Formulation checked
    not checked for this record
    Record checked
    2026-09-29
    Note
    Zealand announced the ZUPREME Phase 3 start on Sep 22, 2026.
  47. Not Yet Recruiting
    Primary completion
    2028-12-21 (estimated)
    Enrollment
    3900 (estimated)
    Last registry update
    2026-09-28
    Source and record notes
    Formulation checked
    Injection
    Record checked
    2026-09-29
    Note
    Zealand announced the ZUPREME Phase 3 start on Sep 22, 2026.
  48. Primary completion
    2026-04-16 (actual)
    Enrollment
    1946 (actual)
    Last registry update
    2026-07-30
    Source and record notes
    Formulation checked
    not checked for this record
    Record checked
    2026-09-29
    Note
    Registry enrollment: 1946 actual; Lilly July 23, 2026 announcement: 1949 randomized. These are separately reported figures; not reconciled.
  49. Primary completion
    2026-04-06 (actual)
    Enrollment
    2335 (actual)
    Last registry update
    2026-08-21
    Source and record notes
    Formulation checked
    Injection
    Record checked
    2026-09-29
    Note
    Registry enrollment: 2335 actual; Lilly May 21, 2026 announcement: 2339 randomized. These are separately reported figures; not reconciled.
  50. Primary completion
    2026-06-16 (actual)
    Enrollment
    1152 (actual)
    Last registry update
    2026-07-30
    Source and record notes
    Formulation checked
    not checked for this record
    Record checked
    2026-09-29
  51. Primary completion
    2025-11-14 (actual)
    Enrollment
    445 (actual)
    Last registry update
    2026-01-21
    Source and record notes
    Formulation checked
    not checked for this record
    Record checked
    2026-09-29
  52. Active Not Recruiting
    Primary completion
    2029-02 (estimated)
    Enrollment
    10000 (estimated)
    Last registry update
    2026-09-24
    Source and record notes
    Formulation checked
    not checked for this record
    Record checked
    2026-09-29
  53. Active Not Recruiting
    Primary completion
    2026-11 (estimated)
    Enrollment
    800 (estimated)
    Last registry update
    2026-07-20
    Source and record notes
    Formulation checked
    not checked for this record
    Record checked
    2026-09-29
  54. Active Not Recruiting
    Primary completion
    2028-04 (estimated)
    Enrollment
    643 (estimated)
    Last registry update
    2026-03-03
    Source and record notes
    Formulation checked
    not checked for this record
    Record checked
    2026-09-29
  55. Active Not Recruiting
    Primary completion
    2027-09 (estimated)
    Enrollment
    586 (estimated)
    Last registry update
    2026-09-25
    Source and record notes
    Formulation checked
    not checked for this record
    Record checked
    2026-09-29
  56. Active Not Recruiting
    Primary completion
    2027-07 (estimated)
    Enrollment
    250 (estimated)
    Last registry update
    2026-04-17
    Source and record notes
    Formulation checked
    not checked for this record
    Record checked
    2026-09-29
  57. Active Not Recruiting
    Primary completion
    2028-10 (estimated)
    Enrollment
    600 (estimated)
    Last registry update
    2026-06-09
    Source and record notes
    Formulation checked
    not checked for this record
    Record checked
    2026-09-29
  58. Ribupatide

    HRS9531 injection in overweight or obesity, China

    NCT06396429 on ClinicalTrials.gov (opens in a new tab)
    Completed
    Primary completion
    2025-07-07 (actual)
    Enrollment
    567 (actual)
    Last registry update
    2025-07-11
    Source and record notes
    Formulation checked
    not checked for this record
    Record checked
    2026-09-29
    Note
    Added after searching earlier drug names/codes in the registry; core fields checked directly in the live v2 response.
  59. Ribupatide

    HRS9531 injection in obesity and sleep apnea

    NCT06974851 on ClinicalTrials.gov (opens in a new tab)
    Recruiting
    Primary completion
    2026-12 (estimated)
    Enrollment
    140 (estimated)
    Last registry update
    2025-11-17
    Source and record notes
    Formulation checked
    not checked for this record
    Record checked
    2026-09-29
    Note
    Added after searching earlier drug names/codes in the registry; core fields checked directly in the live v2 response.
  60. Ribupatide

    HRS9531 injection in obesity and sleep apnea on PAP

    NCT06994650 on ClinicalTrials.gov (opens in a new tab)
    Recruiting
    Primary completion
    2026-12 (estimated)
    Enrollment
    140 (estimated)
    Last registry update
    2026-01-26
    Source and record notes
    Formulation checked
    not checked for this record
    Record checked
    2026-09-29
    Note
    Added after searching earlier drug names/codes in the registry; core fields checked directly in the live v2 response.
  61. Primary completion
    2028-02 (estimated)
    Enrollment
    2340 (estimated)
    Last registry update
    2026-09-03
    Source and record notes
    Formulation checked
    Injection
    Record checked
    2026-09-29
    Note
    Registry fields rechecked directly on 2026-09-29; earlier missing or rounded fields corrected.
  62. Ribupatide

    KaiNETIC-2 (with type 2 diabetes)

    NCT07284901 on ClinicalTrials.gov (opens in a new tab)
    Recruiting
    Primary completion
    2028-03-27 (estimated)
    Enrollment
    1156 (estimated)
    Last registry update
    2026-09-03
    Source and record notes
    Formulation checked
    Injection
    Record checked
    2026-09-29
    Note
    Registry fields rechecked directly on 2026-09-29; earlier missing or rounded fields corrected.
  63. Ribupatide

    KaiNETIC-3 (vs semaglutide)

    NCT07284979 on ClinicalTrials.gov (opens in a new tab)
    Recruiting
    Primary completion
    2028-03 (estimated)
    Enrollment
    1200 (estimated)
    Last registry update
    2026-09-01
    Source and record notes
    Formulation checked
    Injection
    Record checked
    2026-09-29
    Note
    Registry fields rechecked directly on 2026-09-29; earlier missing or rounded fields corrected.
  64. Ribupatide

    HRS9531 injection versus semaglutide, China

    NCT07285902 on ClinicalTrials.gov (opens in a new tab)
    Active Not Recruiting
    Primary completion
    2027-03 (estimated)
    Enrollment
    572 (actual)
    Last registry update
    2026-02-27
    Source and record notes
    Formulation checked
    not checked for this record
    Record checked
    2026-09-29
    Note
    Added after searching earlier drug names/codes in the registry; core fields checked directly in the live v2 response.
  65. Recruiting
    Primary completion
    2027-10-31 (estimated)
    Enrollment
    675 (estimated)
    Last registry update
    2026-08-13
    Source and record notes
    Formulation checked
    oral
    Record checked
    2026-09-29
    Note
    HRS9531 oral tablet Phase 3 study in China; included under ribupatide. This is not the separately planned global oral Phase 3 program.
  66. Ribupatide

    Ribupatide injection in obesity and knee osteoarthritis

    NCT07709910 on ClinicalTrials.gov (opens in a new tab)
    Not Yet Recruiting
    Primary completion
    2028-11 (estimated)
    Enrollment
    382 (estimated)
    Last registry update
    2026-07-17
    Source and record notes
    Formulation checked
    not checked for this record
    Record checked
    2026-09-29
    Note
    Added after searching earlier drug names/codes in the registry; core fields checked directly in the live v2 response.
  67. Primary completion
    2025-12-02 (actual)
    Enrollment
    726 (actual)
    Last registry update
    2026-03-12
    Source and record notes
    Formulation checked
    Injection
    Record checked
    2026-09-29
  68. Primary completion
    2025-12-12 (actual)
    Enrollment
    755 (actual)
    Last registry update
    2026-08-06
    Source and record notes
    Formulation checked
    not checked for this record
    Record checked
    2026-09-29
  69. Completed
    Primary completion
    2026-06-01 (actual)
    Enrollment
    5531 (actual)
    Last registry update
    2026-09-17
    Source and record notes
    Formulation checked
    not checked for this record
    Record checked
    2026-09-29
  70. Primary completion
    2025-12-03 (actual)
    Enrollment
    274 (actual)
    Last registry update
    2026-04-30
    Source and record notes
    Formulation checked
    not checked for this record
    Record checked
    2026-09-29
  71. Completed
    Primary completion
    2025-07-29 (actual)
    Enrollment
    307 (actual)
    Last registry update
    2026-04-30
    Source and record notes
    Formulation checked
    not checked for this record
    Record checked
    2026-09-29
  72. Completed
    Primary completion
    2025-10-09 (actual)
    Enrollment
    218 (actual)
    Last registry update
    2026-04-30
    Source and record notes
    Formulation checked
    not checked for this record
    Record checked
    2026-09-29
  73. Active Not Recruiting
    Primary completion
    2027-07-01 (estimated)
    Enrollment
    1100 (estimated)
    Last registry update
    2026-04-07
    Source and record notes
    Formulation checked
    not checked for this record
    Record checked
    2026-09-29
  74. Active Not Recruiting
    Primary completion
    2027-07-01 (estimated)
    Enrollment
    4500 (estimated)
    Last registry update
    2025-11-24
    Source and record notes
    Formulation checked
    Injection
    Record checked
    2026-09-29
  75. Primary completion
    2029-06-26 (estimated)
    Enrollment
    1150 (estimated)
    Last registry update
    2026-09-24
    Source and record notes
    Formulation checked
    not checked for this record
    Record checked
    2026-09-29
    Note
    Registry fields rechecked directly on 2026-09-29; earlier missing or rounded fields corrected.
  76. Not Yet Recruiting
    Primary completion
    2028-12-12 (estimated)
    Enrollment
    1000 (estimated)
    Last registry update
    2026-03-12
    Source and record notes
    Formulation checked
    not checked for this record
    Record checked
    2026-09-29
    Note
    Added after searching earlier drug names/codes in the registry; core fields checked directly in the live v2 response.
  77. Primary completion
    2028-08-14 (estimated)
    Enrollment
    400 (estimated)
    Last registry update
    2026-07-09
    Source and record notes
    Formulation checked
    not checked for this record
    Record checked
    2026-09-29
    Note
    Added after searching earlier drug names/codes in the registry; core fields checked directly in the live v2 response.
  78. Active Not Recruiting
    Primary completion
    2028-06-06 (estimated)
    Enrollment
    606 (actual)
    Last registry update
    2026-09-11
    Source and record notes
    Formulation checked
    not checked for this record
    Record checked
    2026-09-29
    Note
    Added after searching earlier drug names/codes in the registry; core fields checked directly in the live v2 response.
  79. Primary completion
    2028-08-14 (estimated)
    Enrollment
    400 (estimated)
    Last registry update
    2026-08-17
    Source and record notes
    Formulation checked
    not checked for this record
    Record checked
    2026-09-29
    Note
    Added after searching earlier drug names/codes in the registry; core fields checked directly in the live v2 response.
  80. Primary completion
    2028-08-07 (estimated)
    Enrollment
    630 (estimated)
    Last registry update
    2026-09-04
    Source and record notes
    Formulation checked
    not checked for this record
    Record checked
    2026-09-29
    Note
    Added after searching earlier drug names/codes in the registry; core fields checked directly in the live v2 response.
  81. Primary completion
    2029-07-23 (estimated)
    Enrollment
    5610 (estimated)
    Last registry update
    2026-08-18
    Source and record notes
    Formulation checked
    not checked for this record
    Record checked
    2026-09-29
    Note
    Added after searching earlier drug names/codes in the registry; core fields checked directly in the live v2 response.
  82. Primary completion
    2028-07-12 (estimated)
    Enrollment
    300 (estimated)
    Last registry update
    2026-09-11
    Source and record notes
    Formulation checked
    not checked for this record
    Record checked
    2026-09-29
    Note
    Added after searching earlier drug names/codes in the registry; core fields checked directly in the live v2 response.
  83. Primary completion
    2028-06-26 (estimated)
    Enrollment
    300 (estimated)
    Last registry update
    2026-09-09
    Source and record notes
    Formulation checked
    not checked for this record
    Record checked
    2026-09-29
    Note
    Added after searching earlier drug names/codes in the registry; core fields checked directly in the live v2 response.
  84. Not Yet Recruiting
    Primary completion
    2029-01-11 (estimated)
    Enrollment
    400 (estimated)
    Last registry update
    2026-08-24
    Source and record notes
    Formulation checked
    not checked for this record
    Record checked
    2026-09-29
  85. Primary completion
    2028-10-10 (estimated)
    Enrollment
    650 (estimated)
    Last registry update
    2026-09-28
    Source and record notes
    Formulation checked
    Injection
    Record checked
    2026-09-29
  86. Recruiting
    Primary completion
    2028-06-27 (estimated)
    Enrollment
    950 (estimated)
    Last registry update
    2026-09-28
    Source and record notes
    Formulation checked
    Pill
    Record checked
    2026-09-29
  87. Primary completion
    2029-02-05 (estimated)
    Enrollment
    400 (estimated)
    Last registry update
    2026-09-16
    Source and record notes
    Formulation checked
    not checked for this record
    Record checked
    2026-09-29
    Note
    Added after searching earlier drug names/codes in the registry; core fields checked directly in the live v2 response.
Table 9. All 87 records returned by the disclosed Phase 3 query, September 29, 2026
RecordProgramStudyStatusPrimary completion dateEnrollmentRegistry update
NCT07654361AleniglipronACCOMPLISH-1Recruiting2028-09 (est.)3,600 (est.)2026-08-10
NCT07654374AleniglipronACCOMPLISH-2Recruiting2028-09 (est.)1,100 (est.)2026-09-11
NCT07311850BerobenatideVESPER-4Active, not recruiting2027-09-21 (est.)3,578 (act.)2026-09-24
NCT07400653BerobenatidePF-08653944 in obesity/overweight and type 2 diabetesActive, not recruiting2027-10-12 (est.)1,078 (act.)2026-09-25
NCT07595549BerobenatideVESPER-6 (monthly dosing)Recruiting2028-05-04 (est.)954 (est.)2026-09-28
NCT07792954BerobenatideWeekly berobenatide, ChinaNot yet recruiting2028-03-14 (est.)300 (est.)2026-09-25
NCT07794761BerobenatideVESPER-JWNot yet recruiting2029-03-14 (est.)180 (est.)2026-09-25
NCT07794774BerobenatideVESPER-JMNot yet recruiting2029-02-21 (est.)197 (est.)2026-09-25
NCT07823608BerobenatideVESPER-OSA 1Recruiting2028-04-30 (est.)258 (est.)2026-09-29
NCT07845500BerobenatideSwitching to monthly berobenatide for weight maintenanceNot yet recruiting2028-02-16 (est.)660 (est.)2026-09-29
NCT05394519CagriSemaREDEFINE 2Completed2025-01-28 (act.)1,200 (act.)2026-01-28
NCT05813925CagriSemaCagriSema East Asia studyCompleted2025-01-17 (act.)331 (act.)2026-01-22
NCT05996848CagriSemaREDEFINE 6Completed2025-01-06 (act.)300 (act.)2026-01-09
NCT06131437CagriSemaCagriSema versus tirzepatideCompleted2025-12-08 (act.)809 (act.)2026-02-06
NCT06388187CagriSemaCagriSema dose comparisonCompleted2026-04-22 (act.)300 (act.)2026-05-05
NCT06780449CagriSemaCagriSema long-term weight-loss studyActive, not recruiting2028-08-28 (est.)400 (est.)2026-01-20
NCT07011667CagriSemaCagriSema long-term maintenance studyActive, not recruiting2027-03-01 (est.)609 (act.)2026-07-24
NCT07357766CagriSemaCagriSema formulation comparisonWithdrawn2027-11-29 (est.)0 (act.)2026-07-09
NCT07564414CagriSemaCagriSema doses versus semaglutideRecruiting2028-02-23 (est.)2,500 (est.)2026-08-31
NCT05567796CagriSema; CagrilintideREDEFINE 1Active, not recruiting2024-10-30 (act.)3,400 (est.)2026-08-31
NCT07253285CagriSema; CagrilintideCagrilintide/CagriSema pediatric studyRecruiting2030-03-20 (est.)460 (est.)2026-08-31
NCT07220642CagrilintideRENEW 1Active, not recruiting2027-05-11 (est.)300 (est.)2026-08-06
NCT07220759CagrilintideRENEW 2Active, not recruiting2027-05-12 (est.)330 (est.)2026-09-04
NCT07745504CagrilintideRENEW 4Recruiting2027-05-18 (est.)285 (est.)2026-09-04
NCT07667803ElecoglipronEMBOLD master protocolRecruiting2028-07-31 (est.)4,500 (est.)2026-09-09
NCT07775404ElecoglipronElecoglipron Asian participantsRecruiting2027-06-04 (est.)351 (est.)2026-08-27
NCT07282600EloralintideENLIGHTEN-2Recruiting2028-01 (est.)1,035 (est.)2026-09-22
NCT07321886EloralintideENLIGHTEN-1Recruiting2028-03 (est.)1,980 (est.)2026-09-22
NCT07353931EloralintideENLIGHTEN-4Recruiting2028-03 (est.)900 (est.)2026-09-22
NCT07369011EloralintideENLIGHTEN-3Recruiting2028-03 (est.)800 (est.)2026-09-22
NCT07392190EloralintideENLIGHTEN-6Recruiting2028-06 (est.)900 (est.)2026-09-22
NCT07351045EnicepatideENITH1Recruiting2028-07-24 (est.)2,000 (est.)2026-09-14
NCT07351058EnicepatideENITH2Recruiting2028-08-07 (est.)1,600 (est.)2026-09-14
NCT07670416EnicepatideEnicepatide mixed-diabetes-status studyRecruiting2028-02-24 (est.)300 (est.)2026-09-10
NCT06858839MariTideMARITIME-1Active, not recruiting2027-01-21 (est.)3,853 (act.)2026-09-17
NCT06858878MariTideMARITIME-2Active, not recruiting2027-01-21 (est.)1,105 (act.)2025-12-31
NCT06987695MariTideMARITIME-3-JActive, not recruiting2027-04-27 (est.)279 (act.)2025-12-17
NCT07037433MariTideMARITIME-CVRecruiting2028-06-30 (est.)12,800 (est.)2026-09-22
NCT07037459MariTideMARITIME-HFRecruiting2028-06-30 (est.)5,056 (est.)2026-09-16
NCT07225686MariTideMARITIME-OSA-1Active, not recruiting2027-09-03 (est.)250 (est.)2026-09-18
NCT07226765MariTideMARITIME-OSA-2Active, not recruiting2027-08-30 (est.)250 (est.)2026-09-29
NCT07575399MariTideMARITIME-SWITCHRecruiting2028-01-03 (est.)300 (est.)2026-08-27
NCT07684144MariTideMARITIME-2-EXTENSIONRecruiting2027-12-26 (est.)950 (est.)2026-09-03
NCT07684235MariTideMARITIME-1-EXTENSIONRecruiting2027-12-26 (est.)3,200 (est.)2026-09-03
NCT07843472PetrelintideZUPREME-5Not yet recruiting2030-07-28 (est.)2,500 (est.)2026-09-28
NCT07843485PetrelintideZUPREME-4Not yet recruiting2028-10-20 (est.)600 (est.)2026-09-28
NCT07843498PetrelintideZUPREME-3Not yet recruiting2028-12-21 (est.)3,900 (est.)2026-09-28
NCT05882045RetatrutideTRIUMPH-3Completed2026-04-16 (act.)1,946 (act.)2026-07-30
NCT05929066RetatrutideTRIUMPH-1Completed2026-04-06 (act.)2,335 (act.)2026-08-21
NCT05929079RetatrutideTRIUMPH-2Completed2026-06-16 (act.)1,152 (act.)2026-07-30
NCT05931367RetatrutideTRIUMPH-4Completed2025-11-14 (act.)445 (act.)2026-01-21
NCT06383390RetatrutideTRIUMPH-OutcomesActive, not recruiting2029-02 (est.)10,000 (est.)2026-09-24
NCT06662383RetatrutideTRIUMPH-5Active, not recruiting2026-11 (est.)800 (est.)2026-07-20
NCT06859268RetatrutideTRIUMPH-6Active, not recruiting2028-04 (est.)643 (est.)2026-03-03
NCT07035093RetatrutideTRIUMPH-7Active, not recruiting2027-09 (est.)586 (est.)2026-09-25
NCT07232719RetatrutideTRIUMPH-8Active, not recruiting2027-07 (est.)250 (est.)2026-04-17
NCT07357415RetatrutideTRIUMPH-9Active, not recruiting2028-10 (est.)600 (est.)2026-06-09
NCT06396429RibupatideHRS9531 injection in overweight or obesity, ChinaCompleted2025-07-07 (act.)567 (act.)2025-07-11
NCT06974851RibupatideHRS9531 injection in obesity and sleep apneaRecruiting2026-12 (est.)140 (est.)2025-11-17
NCT06994650RibupatideHRS9531 injection in obesity and sleep apnea on PAPRecruiting2026-12 (est.)140 (est.)2026-01-26
NCT07284875RibupatideKaiNETIC-1Recruiting2028-02 (est.)2,340 (est.)2026-09-03
NCT07284901RibupatideKaiNETIC-2 (with type 2 diabetes)Recruiting2028-03-27 (est.)1,156 (est.)2026-09-03
NCT07284979RibupatideKaiNETIC-3 (vs semaglutide)Recruiting2028-03 (est.)1,200 (est.)2026-09-01
NCT07285902RibupatideHRS9531 injection versus semaglutide, ChinaActive, not recruiting2027-03 (est.)572 (act.)2026-02-27
NCT07670884RibupatideHRS9531 tablets, ChinaRecruiting2027-10-31 (est.)675 (est.)2026-08-13
NCT07709910RibupatideRibupatide injection in obesity and knee osteoarthritisNot yet recruiting2028-11 (est.)382 (est.)2026-07-17
NCT06066515SurvodutideSYNCHRONIZE-1Completed2025-12-02 (act.)726 (act.)2026-03-12
NCT06066528SurvodutideSYNCHRONIZE-2Completed2025-12-12 (act.)755 (act.)2026-08-06
NCT06077864SurvodutideSYNCHRONIZE-CVOTCompleted2026-06-01 (act.)5,531 (act.)2026-09-17
NCT06176365SurvodutideSYNCHRONIZE-JPCompleted2025-12-03 (act.)274 (act.)2026-04-30
NCT06214741SurvodutideSurvodutide China studyCompleted2025-07-29 (act.)307 (act.)2026-04-30
NCT06309992SurvodutideSYNCHRONIZE-MASLDCompleted2025-10-09 (act.)218 (act.)2026-04-30
NCT07104383VK2735 (injection)VANQUISH 2Active, not recruiting2027-07-01 (est.)1,100 (est.)2026-04-07
NCT07104500VK2735 (injection)VANQUISH 1Active, not recruiting2027-07-01 (est.)4,500 (est.)2025-11-24
NCT07339423ZenagamtideAMAZE 1Recruiting2029-06-26 (est.)1,150 (est.)2026-09-24
NCT07400107ZenagamtideAMAZE 8Not yet recruiting2028-12-12 (est.)1,000 (est.)2026-03-12
NCT07481630ZenagamtideAMAZE 5Recruiting2028-08-14 (est.)400 (est.)2026-07-09
NCT07503210ZenagamtideAMAZE 12Active, not recruiting2028-06-06 (est.)606 (act.)2026-09-11
NCT07509307ZenagamtideAMAZE 6Recruiting2028-08-14 (est.)400 (est.)2026-08-17
NCT07533175ZenagamtideAMAZE 2Recruiting2028-08-07 (est.)630 (est.)2026-09-04
NCT07567001ZenagamtideHF-POLARISRecruiting2029-07-23 (est.)5,610 (est.)2026-08-18
NCT07571005ZenagamtideAMAZE 3Recruiting2028-07-12 (est.)300 (est.)2026-09-11
NCT07571109ZenagamtideAMAZE 4Recruiting2028-06-26 (est.)300 (est.)2026-09-09
NCT07668401ZenagamtideAMAZE 13Not yet recruiting2029-01-11 (est.)400 (est.)2026-08-24
NCT07668414ZenagamtideAMAZE 7Recruiting2028-10-10 (est.)650 (est.)2026-09-28
NCT07720271ZenagamtideAMAZE 9 (tablets)Recruiting2028-06-27 (est.)950 (est.)2026-09-28
NCT07822061ZenagamtideAMAZE 10Recruiting2029-02-05 (est.)400 (est.)2026-09-16

Source: ClinicalTrials.gov, one row per record, linked; compiled by Weight Loss Provider Guide Research, checked September 29, 2026. "Est." = estimated; "Act." = actual. Enrollment is the record's own number and can include people counted in another record (extensions), so don't add them up.

Why do drug names and counts get mixed up?

One drug can have three or four names, and one trial record can cover two drugs or two studies. That's how the same pipeline turns into different counts. Here's the name key.

Table 10. Drug name key
Name used hereOther names and codes
CagriSemacagrilintide + semaglutide
RetatrutideLY3437943
SurvodutideBI 456906
MariTidemaridebart cafraglutide; AMG 133
EloralintideLY3841136
Zenagamtideamycretin; NNC0487-0111; NN9487
Cagrilintidecagrilintide 2.4 mg alone
VK2735(shot and pill formulations have separate studies)
AleniglipronGSBR-1290
ElecoglipronAZD5004; ECC5004
BerobenatidePF-08653944; PF'3944; MET-097i; MET097; MET-097
EnicepatideCT-388; RO7795068; RG6640
RibupatideKAI-9531; HRS9531
PetrelintideZP8396; RO7895515

Source: company releases and ClinicalTrials.gov records linked in Table 1 and the dataset; checked September 29, 2026.

Amycretin and zenagamtide are the same drug

Novo Nordisk renamed amycretin as zenagamtide. Count it once. One of its Phase 3 trials, AMAZE 1, is filed under the code NNC0487-0111, so a search for "zenagamtide" alone can miss it (ClinicalTrials.gov NCT07339423).

One record, two drugs

One trial in children and teens tests both CagriSema and cagrilintide (NCT07253285). It shows up under both drugs. In any total, it counts once. REDEFINE 1 also has separate CagriSema and cagrilintide-alone arms (NCT05567796). Both records count under both programs, but each counts once in the registry total. That is why the program counts add up to 89 memberships, while the registry has 87 unique records.

One record, two studies

AstraZeneca's EMBOLD record covers two separate main studies under one number (NCT07667803). So 87 records is not the same as 87 separate studies.

What changed in the obesity pipeline in the past year?

The FDA approved two oral GLP-1 medicines for weight loss, a higher-dose Wegovy shot and a new use for Imcivree between December 2025 and April 2026. CagriSema was filed, and Zealand announced petrelintide’s Phase 3 initiation on September 22, 2026. These changes matter because older lists can mix approved drugs with experimental ones.

Table 11. Pipeline changes, December 2025 to September 2026
DateDrugWhat happenedType
2025-12-18CagriSemaNovo Nordisk filed for FDA approval for weight managementFDA filing
2025-12-22Wegovy pill (oral semaglutide 25 mg)FDA approved the first GLP-1 pill for weight lossFDA approval
2026-03-19Wegovy HD (semaglutide 7.2 mg)FDA approved the higher-dose Wegovy shotFDA approval
2026-03-19Imcivree (setmelanotide)FDA approved it for acquired hypothalamic obesity, a rare formFDA approval (new use)
2026-04-01Foundayo (orforglipron)FDA approved Lilly's small-molecule GLP-1 pill for weight managementFDA approval
2026-06-29ElecoglipronAstraZeneca's EMBOLD Phase 3 startedPhase 3 start
2026-07-23RetatrutideLilly said it plans to file with the FDA in Q1 2027Company filing plan
2026-07-13AleniglipronACCOMPLISH-1 lists this actual study start date in the registry; sponsor separately announced first patients dosed in its Q2 2026 updatePhase 3 start
2026-09-22PetrelintideZealand announced ZUPREME Phase 3 initiation; all three selected records still listed not yet recruiting on September 28Phase 3 initiation announcement
2026-09-21CagriSemaNovo reported REIMAGINE 5 and REDEFINE 9 results and forecast a Q4 2026 FDA decision; still investigationalResults and company decision forecast
2026-09-28EmugrobartChugai announced discontinuation of obesity development; plans for a different condition remain separateObesity development stopped

Source: each company or the FDA-approval announcement, linked; compiled by Weight Loss Provider Guide Research, checked September 29, 2026.

Related developments and formulations to watch

Table 12. Watchlist, September 29, 2026
DrugVerified developmentHow it relates to this trackerDate or planned window
VK2735 (pill)Viking expects to start an oral Phase 3Oral Phase 3 is a dated company plan; injection remains in the 142026-Q4 (planned)
BivamelagonRhythm's February 26, 2026 update planned Phase 3 in acquired hypothalamic obesity by year-end; this is a dated planRare acquired hypothalamic obesity is outside the selected list2026 year-end (planned)
Ribupatide (pill)Kailera plans global oral Phase 3 as early as 1H 2027; separate China oral Phase 3 record NCT07670884 is already recruitingChina oral record is included; global oral plan is separate2027 1H at earliest (planned)
MazdutideNMPA approved mazdutide in China for chronic weight managementRegional approval example outside this selected list2025-06-27
EcnoglutideApproved in China for chronic weight managementRegional approval example outside this selected list2026-03-06
ARD-101Aardvark ended its Phase 3 HERO trial in Prader-Willi syndrome after an FDA clinical holdHERO trial ended; not evidence that all future development ended2026-06

Source: company announcements and the Aardvark SEC filing, linked; checked September 29, 2026. Planned windows are not completed milestones.

Can I get these drugs now?

None of these 14 selected programs had FDA weight-management approval in the sources checked. Trial participation is not the same as routine prescribing. FDA also has an expanded-access pathway for some people with serious conditions when no satisfactory alternative is available; that requires separate medical and regulatory review and does not establish access to a particular drug (FDA).

A product sold online as “retatrutide” is not an FDA-approved retatrutide medicine. The drug name on an offer does not establish approval, quality or trial access.

To ask about joining a study, open a trial number from Table 9 on ClinicalTrials.gov and look for sites marked "recruiting" near you. The study team decides who qualifies.

If you'd rather start with something approved now, here are current self-pay prices for the Wegovy pill, Foundayo and other brand-name GLP-1s. Our GLP-1 Telehealth Pricing Index tracks what online programs charge.

How we built this tracker

Drug list. On September 29, 2026, we reviewed the 14 selected drug or combination programs in this reference against company releases, investor reports, SEC filings and trial records. We checked each program’s reported stage, names, target and form. We checked approval announcements separately. This was not an exhaustive search for every candidate worldwide. A program can have trials in several countries; “not FDA-approved” describes its U.S. weight-management status, not the location of every trial.

Trial records. We retrieved Phase 3 records from the ClinicalTrials.gov v2 API on September 29, 2026. The expanded name-and-code query returned 87 records. A separate identifiers-only pull also returned the same 87 NCT numbers; there was no next-page token. We kept one row per NCT number and copied each record’s status, primary completion date, date type, enrollment and last update as listed.

The query uses query.cond=obesity, filter.advanced=AREA[Phase]PHASE3, pageSize=100, countTotal=true and the following intervention names and codes:

CagriSema OR retatrutide OR LY3437943 OR cagrilintide OR NNC0174-0833 OR survodutide OR "BI 456906" OR maridebart OR "AMG 133" OR VK2735 OR petrelintide OR ZP8396 OR RO7895515 OR eloralintide OR LY3841136 OR zenagamtide OR amycretin OR NNC0487-0111 OR NN9487 OR CT-388 OR enicepatide OR RO7795068 OR RG6640 OR aleniglipron OR GSBR-1290 OR elecoglipron OR AZD5004 OR ECC5004 OR berobenatide OR PF-08653944 OR MET-097i OR MET-097 OR ribupatide OR KAI-9531 OR HRS9531

Run the exact registry query. The 87-record snapshot is preserved in the CSV; a live rerun can return later changes.

Checks. Every record’s core fields were checked in the live API response. We read descriptions and intervention details more closely where they affected a public claim: the two shared CagriSema/cagrilintide records, the China oral ribupatide record and the EMBOLD master protocol. We separately checked the dated start milestones shown here. This does not mean every field in every full protocol received a second-source review. A blank or “not checked” detail in our download is not a claim that the registry lacks that detail.

Counting. We count NCT identifiers, not patients or independent studies. Two records have separate CagriSema and cagrilintide-alone arms, so 89 program memberships become 87 unique records. “Ongoing or planned” includes recruiting, active/not recruiting and not yet recruiting: 38 + 22 + 10 = 70. Of those, 69 have estimated primary completion dates and one has an actual date. We group estimated dates by their recorded year and keep the source’s day or month precision.

Source differences. The registry and a company announcement can report different enrollment figures. We preserve the registry number in the CSV and show the company figure separately; the sources checked do not resolve these differences:

  • Trial: TRIUMPH-1
    • Registry field checked September 29, 2026: 2,335, actual enrollment
    • Company announcement: 2,339 randomized
    • Sources: Registry; Lilly, May 21, 2026
  • Trial: TRIUMPH-3
    • Registry field checked September 29, 2026: 1,946, actual enrollment
    • Company announcement: 1,949 randomized
    • Sources: Registry; Lilly, July 23, 2026
  • Trial: REDEFINE 1

Results and publisher counts. Trial results come from the named company or its filing, with the trial, duration and analysis kept together. We did not calculate a pooled weight-loss result. The count audit checks what each public publisher page says; it does not verify the contents of paid pipeline reports. Those reported counts are not inputs to our 14-program or 87-record totals.

To reproduce it: use the exact API query, compare its returned NCT identifiers with the trial CSV, then filter by the status and date-type fields described above. Live results can change. The dated CSV preserves the values used for this page; a later query is a later snapshot, not proof of a change on September 29.

What we excluded: records outside the disclosed Phase 3 query and programs outside the selected 14. The matched records include multinational, pediatric, extension, cardiovascular, sleep-apnea and other obesity-related studies—not only adult weight-loss efficacy trials. We do not add separate program rows for a pill and shot of the same drug. Regional approvals and additional programs are discussed separately where useful.

What this data shows, and what it doesn't

It shows a dated reference for 14 selected programs: their reported stages, targets, forms, selected trial results and 87 matched Phase 3 registry records. It does not establish that these are all the programs meeting those broad criteria.

It doesn't show which drug works best (no trial here compares them all), when any drug will launch, what any drug will cost, whether insurance will cover it, or whether it's right for you. It's not a count of every obesity drug worldwide. A search can miss a record filed under an unexpected name. Registry fields come from the trial sponsors and can lag.

This is general information, not medical advice. Talk with a licensed clinician about weight-loss treatment.

How to cite this page

WPG Research Team. “Obesity Drugs in Development: 87 Trial Records for 14 Programs.” Weight Loss Provider Guide. Data checked September 29, 2026. https://weightlossproviderguide.com/research/obesity-drug-pipeline. Accessed [insert access date].

Reuse: Our original compilation and charts may be reused under CC BY 4.0 to the extent we own or may license them; credit Weight Loss Provider Guide Research for that contribution and preserve the underlying sources’ attribution and terms. No link is required.

Download the data

Four free CSV files. No sign-up, no email. Every row carries its source link and check date.

Frequently asked questions

What new weight-loss drugs are coming in 2026?

CagriSema is the one program in this selected set with a documented FDA filing. Novo’s September 21 update forecast a decision in Q4 2026, not a guaranteed launch. Two oral GLP-1 medicines for weight loss were already approved: the Wegovy pill on December 22, 2025, and Foundayo on April 1, 2026 (Novo; approval dates).

When will retatrutide be released in the USA?

The sources checked do not establish a confirmed U.S. release date. Lilly plans an FDA submission in Q1 2027; a submission is not approval (Lilly, July 23, 2026). Trial access and any separately authorized expanded access are not routine commercial availability (FDA).

What is the newest medication for obesity?

Foundayo (orforglipron) is the new active drug in the approval events covered here: FDA approved it on April 1, 2026 (FDA). FDA also approved higher-dose Wegovy and a new Imcivree use for acquired hypothalamic obesity on March 19, 2026. A new drug, a new dose and a new use are different types of approval (approval table).

How many obesity drugs are in development?

The selected publisher counts range from 13 to more than 200, but their scopes differ. Our tracker covers 14 selected programs and 87 matched Phase 3 records as of September 29, 2026—not the whole global pipeline (count audit; method).

Is there a new weight-loss pill coming?

Four programs in this reference have an oral Phase 3 record: aleniglipron, elecoglipron, zenagamtide and ribupatide; ribupatide’s tablet trial is in China (pill table). Viking’s July 29, 2026 update planned oral VK2735 Phase 3 for Q4 2026 (Viking). A company plan is not a completed start.

What obesity drugs does Eli Lilly have in the pipeline?

Two are on this list: retatrutide, with Phase 3 results and a planned Q1 2027 FDA filing, and eloralintide, with Phase 3 records (Lilly; ENLIGHTEN-1). This is not a complete list of Lilly’s research programs. Zepbound and Foundayo are already approved products, not part of this selected first-approval pipeline (Lilly).

Are amycretin and zenagamtide the same drug?

Yes. Zenagamtide is the newer name for amycretin, so count it once. Some trial records use its code, NNC0487-0111 (Novo Nordisk; AMAZE 1).

Can I join a trial marked "recruiting"?

Maybe. Thirty-eight of the 87 matched Phase 3 records listed “recruiting” on September 29, 2026, but each study has its own sites and rules (records). Open the record on ClinicalTrials.gov to find sites and contacts; the study team decides who qualifies.

Why do reports give two weight-loss numbers for the same drug?

A trial may estimate both continued-treatment and treatment-policy effects, using its rules for missing data and other treatments. Retatrutide’s TRIUMPH-4 study reported 28.7% and 23.7% for its 12 mg arm at 68 weeks—a 5.0-percentage-point gap, not a 5% relative gap (Lilly).

What is amylin?

Amylin is a hormone your pancreas releases with insulin after meals; it helps you feel full. Five of the 14 selected programs act on amylin receptors. None of those five had FDA weight-management approval in the sources checked (mechanisms and sources).

Sources

All checked September 29, 2026. Trial and publication dates below are not the check date. Company results are attributed reports, not independent replications.

  1. Eli Lilly. TRIUMPH-1 results. May 21, 2026.
  2. Eli Lilly. TRIUMPH-2/3 results and FDA filing plan. July 23, 2026.
  3. Eli Lilly. TRIUMPH-4 results. December 11, 2025.
  4. Eli Lilly. Eloralintide Phase 2 results. November 6, 2025.
  5. Novo Nordisk. CagriSema FDA filing. December 18, 2025.
  6. Novo Nordisk. REDEFINE 1 results, Form 6-K. December 20, 2024.
  7. Novo Nordisk. REIMAGINE 5/REDEFINE 9 results and FDA decision forecast. September 21, 2026.
  8. Novo Nordisk. Annual Report 2025: innovation and therapeutic focus. 2025 reporting period.
  9. Boehringer Ingelheim. SYNCHRONIZE-1 results. April 28, 2026.
  10. Amgen. Phase 2 MariTide results and estimands. June 23, 2025.
  11. Viking Therapeutics. Q2 results, VANQUISH and oral development. July 29, 2026.
  12. Structure Therapeutics. ACCESS II results. March 16, 2026.
  13. Structure Therapeutics. Q2 2026 financial results and first Phase 3 dosing. Q2 2026 update.
  14. AstraZeneca. Elecoglipron VISTA results and Phase III program. June 8, 2026.
  15. Pfizer. VESPER-3 28-week results. February 3, 2026.
  16. Pfizer. Berobenatide development update. June 6, 2026.
  17. Roche. CT-388/enicepatide Phase II results. January 27, 2026.
  18. Hengrui and Kailera. GEMINI-1 China Phase 3 results. November 4, 2025.
  19. Kailera. Q2 2026 results and oral/global plans. August 12, 2026.
  20. Zealand Pharma. ZUPREME Phase 3 initiation. September 22, 2026.
  21. Zealand Pharma. ZUPREME-1 results and estimands. Posted September 29, 2026 U.S. time; datelined September 30 in Denmark.
  22. FDA. Foundayo approval. April 1, 2026.
  23. Novo Nordisk. U.S. Wegovy pill approval. December 22, 2025.
  24. FDA. Higher-dose Wegovy approval. March 19, 2026.
  25. Rhythm. FDA approval of Imcivree for acquired hypothalamic obesity. March 19, 2026.
  26. Rhythm. Q4/full-year 2025 results and bivamelagon plan. February 26, 2026.
  27. Innovent. NMPA approval of mazdutide for weight management. June 27, 2025.
  28. Sciwind. NMPA approval of ecnoglutide for weight management. March 6, 2026.
  29. Aardvark. Quarterly SEC filing: HERO trial termination. Period ended June 30, 2026.
  30. Chugai. Discontinuation of obesity development for emugrobart. September 28, 2026.
  31. Original receptor research, Monash record. AM833/cagrilintide activity at calcitonin-family receptors. 2021.
  32. Aphaia. Second Phase 2 obesity study. September 9, 2025.
  33. FDA. Expanded access. Current guidance page.
  34. FDA. Clinical research phases. Current explanatory page.
  35. ClinicalTrials.gov. Glossary: dates and study status. Current registry definitions.
  36. Becker's Hospital Review. Public pipeline-count page. 2026-09-02. Public stated count only; underlying paid data not recounted.
  37. GoodRx. Public pipeline-count page. 2026-07-23 (page date); title checked 2026-09-29. Public stated count only; underlying paid data not recounted.
  38. Expert Market Research. Public pipeline-count page. 2026 (report page). Public stated count only; underlying paid data not recounted.
  39. IQVIA. Public pipeline-count page. 2026-02-19. Public stated count only; underlying paid data not recounted.
  40. Ozmosi. Public pipeline-count page. 2026-08-17 (page date); checked 2026-09-29. Public stated count only; underlying paid data not recounted.
  41. ResearchAndMarkets (GlobeNewswire release). Public pipeline-count page. 2026-09-23. Public stated count only; underlying paid data not recounted.
  42. ClinicalTrials.gov. Exact selected-program query; individual record URLs in Table 9 and the trial CSV. Snapshot checked September 29, 2026.

GLP-1 Consumer Research is the research and reference section of Weight Loss Provider Guide.